Oruka Therapeutics, Inc. (ORKA) Stock Price & Analysis
Oruka Therapeutics, Inc. (ORKA) rose 0.23% to USD 92.16 as of July 25, 2026 at 03:50 UTC, according to Nexqual real-time market data.
ORKA last closed at USD 91.95; the session ranged USD 90.32–94.49 on volume of 510,325 shares. Market capitalization is $5.56B, with a 52-week range of USD 12.84–97.78 (NGM). Source: Nexqual, July 25, 2026 at 03:50 UTC.
Key Statistics (as of July 25, 2026 at 03:50 UTC)
| Price | USD 92.16 |
|---|---|
| Change | ▲ 0.23% (up) |
| Previous Close | USD 91.95 |
| Open | USD 92.51 |
| Day Range | USD 90.32 – 94.49 |
| 52-Week Range | USD 12.84 – 97.78 |
| Volume | 510,325 shares |
| Market Cap | $5.56B |
| Exchange | NGM |
Technical Analysis (ORKA)
Nexqual's technical model rates ORKA "STRONG BUY" based on 5 bullish and 0 bearish signals across 125 daily candles, as of July 25, 2026 at 03:50 UTC.
| Overall Signal | STRONG BUY |
|---|---|
| RSI (14) | 63.53 (neutral) |
| vs SMA50 | Above (USD 74.8) |
| MACD | 4.54 (positive) |
Analyst Ratings (ORKA)
Wall Street analysts rate ORKA "Strong Buy" based on 12 analysts, with a mean price target of USD 148.17 (range USD 102–200), per Nexqual as of July 25, 2026 at 03:50 UTC.
| Consensus Rating | Strong Buy |
|---|---|
| Analyst Count | 12 |
| Mean Target | USD 148.17 |
| High Target | USD 200 |
| Low Target | USD 102 |
| Buy / Hold / Sell | 13 / 0 / 0 |
Earnings (ORKA)
| Next Earnings Date | 2026-08-10 |
|---|---|
| EPS Estimate | USD -0.5 |
| Revenue Estimate | $0 |
Recent Earnings History
| Quarter | Actual vs Estimate |
|---|---|
| 2026-03-31 | USD -0.48 vs est -0.54 ▲ beat |
| 2025-12-31 | USD -0.45 vs est -0.62 ▲ beat |
| 2025-09-30 | USD -0.55 vs est -0.52 ▼ miss |
| 2025-06-30 | USD -0.46 vs est -0.43 ▼ miss |
Source: Nexqual, July 25, 2026 at 03:50 UTC.
Financials & Fundamentals (ORKA)
| Gross Margin | +0.00% |
|---|---|
| Operating Margin | +0.00% |
| Profit Margin | +0.00% |
| ROE | -27.31% |
| Debt / Equity | 0.37 |
| Current Ratio | 23.76 |
| Total Cash | $388.83M |
| Total Debt | $1.81M |
| Free Cash Flow | $-56.13M |
Source: Nexqual, July 25, 2026 at 03:50 UTC.
Financial Health Score (ORKA)
Nexqual rates Oruka Therapeutics, Inc.'s overall financial health "Mixed" across five dimensions, as of July 25, 2026 at 03:50 UTC.
| Growth | Mixed — No data |
|---|---|
| Profitability | Weak — Pre-revenue or very early stage |
| Balance Sheet | Strong — $389M cash vs $2M debt, net cash position |
| Cash Flow | Weak — Operating cash flow -$91M |
| Efficiency | Critical — ROE -27%, ROA -18.9% |
Ownership (ORKA)
| Insider Ownership | +1.23% |
|---|---|
| Institutional Ownership | +95.49% |
| Shares Outstanding | 60.31M |
| Float | 51.09M |
| Short % of Float | +23.15% |
Source: Nexqual, July 25, 2026 at 03:50 UTC.
Leadership (ORKA)
Oruka Therapeutics, Inc. is led by Lawrence Otto Klein (age 42), President, CEO & Director, per Nexqual as of July 25, 2026 at 03:50 UTC.
| President, CEO & Director | Lawrence Otto Klein (age 42) |
|---|
Major Backers & Investors (ORKA)
Notable institutional backers of Oruka Therapeutics, Inc. include FMR, LLC, Venrock Adviser, LLC, Fidelity, according to Nexqual as of July 25, 2026 at 03:50 UTC.
Active Investors
| Investor | Stake |
|---|---|
| FMR, LLC | 12.32% |
| Venrock Adviser, LLC | 6.88% |
| Fidelity | 6.69% |
| Fairmount Funds Management LLC | 6.14% |
| Viking Global | 4.42% |
| Paradigm Biocapital Advisors LP | 3.85% |
| RTW Investments LP | 3.41% |
Index Funds (Passive)
| Fund | Stake |
|---|---|
| BlackRock | 7.69% |
| Vanguard Group | 6.08% |
| State Street | 5.25% |
Source: Nexqual, July 25, 2026 at 03:50 UTC.
From Oruka Therapeutics, Inc.'s Latest SEC 10-K Filing (filed 2026-03-12)
Key Strengths & Strategy (as disclosed to the SEC)
- We and Paragon have also filed, and may continue to file, patent applications relating to antibodies that target IL-17, including applications covering composition of matter, pharmaceutical formulations, and methods of use, including for ORKA-002.   We hold exclusive rights to ORKA-001 and ORKA-002, as well as the associated IL-23 and IL-17 patent rights, pursuant to license agreements with Paragon.
- Our strategy is to apply antibody engineering and format innovations to validated modes of action, which we believe will enable us to improve meaningfully upon the efficacy and dosing regimens of standard-of-care medicines while significantly reducing technical and biological risk.
- We believe this approach will enable us to improve meaningfully upon the efficacy and convenience of standard-of-care medicines while significantly reducing technical and biological risk.
Partnerships
- In September 2024, we exercised our exclusive option to acquire certain rights to ORKA-001, and in December 2024, we entered into a corresponding license agreement with Paragon pursuant to which Paragon granted us a royalty-bearing, world-wide, exclusive license to develop, manufacture, commercialize or otherwise exploit certain antibodies and products targeting IL-23 in all fields other than the field of inflammatory bowel disease.
- As of December 31, 2025, we have not entered into a license agreement with Paragon and Paruka related to this additional option agreement.   15     Cell Line License Agreement   In March 2024, we entered into the Cell Line License Agreement (the "Cell Line License Agreement") with WuXi Biologics Ireland Limited ("WuXi Biologics").
Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.
Peers & Related Stocks
| Symbol | Name | Price | Change |
|---|---|---|---|
| SYRE | Spyre Therapeutics, Inc. | USD 102.13 | ▲ 2.98% |
| DNTH | Dianthus Therapeutics, Inc. | USD 103.87 | ▲ 1.08% |
| APGE | Apogee Therapeutics, Inc. | USD 134.28 | ▲ 0.15% |
| ELVN | Enliven Therapeutics, Inc. | USD 52.95 | ▲ 0.19% |
| TNGX | Tango Therapeutics, Inc. | USD 26.63 | ▼ 5.23% |
Data source: Nexqual — real-time market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: July 25, 2026 at 03:50 UTC. This page is informational and not investment advice.