Alnylam Pharmaceuticals, Inc. (ALNY) Stock Price & Analysis

Alnylam Pharmaceuticals, Inc. (ALNY) is trading at USD 223.24, down 1.78% today, as of October 23, 2026 at 15:07 UTC (US market open; quotes may be delayed), according to Nexqual market data.

ALNY last closed at USD 227.28; today's session has ranged USD 222–227.28 on volume of 239,900 shares. Market capitalization is $29.87B, with a 52-week range of USD 197.81–485.36 (NMS). Source: Nexqual, retrieved October 23, 2026 at 15:07 UTC.

Also available as compact Markdown for AI agents: nexqual.com/ALNY.md

Key facts (ALNY)

Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (ALNY)

USDFY2021FY2022FY2023FY2024FY2025TTM
Revenue$844M$1.04B$1.83B$2.25B$3.71B—
Gross profit$729M$897M$1.56B$1.94B$3.04B—
Operating income-$709M-$785M-$282M-$177M$502M—
Net income-$853M-$1.13B-$440M-$278M$314M$733M
EPS (diluted)-$7.20-$9.30-$3.52-$2.18$2.33—
Free cash flow-$718M-$613M$41.9M-$42.6M$465M—
Gross margin86.4%86.5%85.3%86.4%81.8%—
Operating margin-83.9%-75.7%-15.4%-7.9%13.5%—
Net margin-101.0%-109.0%-24.1%-12.4%8.4%—
Revenue growth+71.3%+22.9%+76.2%+23.0%+65.2%—
Cash + short-term investments$2.37B$2.16B$2.43B$2.69B$2.91B—
Total debt$676M$1.02B$1.02B$1.02B$1.01B—

Fiscal years end Dec. EPS is split-adjusted.

Valuation (price ÷ last four quarters, through Jun 30, 2026) (ALNY)

P/E 40.7x · P/B 22.1x · Earnings yield 2.45% · Net cash $2.30B · EV $27.6B

P/E at fiscal year-ends: Dec 2025 170.7x.

Superinvestors (SEC 13F-HR, Q2 2026) (ALNY)

1 of 80 tracked investors hold ALNY. Each row is the investor's latest 13F; change is vs their prior-quarter share count.

InvestorFirm% of portfolioValueChange
Dodge & Cox FundsDodge & Cox0.31%$589MAdded +1.4%

Insider sales (SEC Form 4, open-market, last ~7 months) (ALNY)

2 of 3 under a Rule 10b5-1 trading plan (scheduled in advance). Unplanned sales were timed by the insider.

Trade dateInsiderRoleSharesValue% of holdings sold10b5-1 planInsider type
2026-10-02Supran BryanEVP, CLO and Secretary1,758$399K12.1%NoToo little history (no open-market trades in 2023–2025)
2026-06-01Pyott David E IDirector3,830$1.1M11.5%Yes (adopted November 12, 2025)Too little history (no open-market trades in 2023)
2026-04-02…2026-04-06McLaughlin MelissaChief Human Resources Officer3,910$1.3M29.3%Yes (adopted December 16, 2025)Too little history (no open-market trades in 2023–2025)

% of holdings sold = shares sold ÷ (shares sold + all holdings the insider reported on that Form 4, direct and through trusts).

Insider type follows Cohen, Malloy & Pomorski (Journal of Finance, 2012). An insider who traded the stock in the same calendar month in each of the past three years is a routine trader; one who traded in each of those years without such a pattern is an opportunistic trader. In their study, trades by opportunistic insiders predicted future returns and trades by routine insiders did not. Counts open-market purchases and sales only (SEC Form 4 codes P and S) by that insider in that company. Not investment advice.

Analysts (ALNY)

Consensus Buy (mean 2.03 on a 1–5 scale), 30 analysts; mean target USD 368.7 (low 250, high 536).

Rating changes, last 120 days:

DateFirmActionRatingPrice target
2026-10-14CitigroupTarget loweredBuy$340 → $320
2026-10-14Wells FargoTarget loweredEqual-Weight$256 → $253
2026-10-08RBC CapitalTarget loweredOutperform$350 → $345
2026-09-30JP MorganTarget loweredOverweight$375 → $369
2026-09-21HC Wainwright & Co.ReiteratedBuy$455
2026-09-08JefferiesTarget raisedHold$230 → $260
2026-09-02HC Wainwright & Co.ReiteratedBuy$455
2026-08-19BMO CapitalInitiatedOutperform$318
2026-08-14Wells FargoTarget loweredEqual-Weight$316 → $256
2026-08-04Truist SecuritiesTarget loweredBuy$410 → $315
2026-08-04HC Wainwright & Co.Target loweredBuy$485 → $455
2026-08-03Raymond JamesUpgradeOutperform → Strong Buy$420

Total return (dividends reinvested) (ALNY)

1Y (from 2025-10-23)5Y (from 2021-10-25)
Total return-51.9%+39.9%
S&P 500 (SPY)+14.8%+77.5%
Per year-51.9%+7.0%
Volatility (annualized)51.4%49.4%
Max drawdown-57.3% (Oct 2025→Jul 2026)-57.3% (Oct 2025→Jul 2026)

ALNY revenue by product line (quarter ended Jun 30, 2026)

LineRevenueShare of totalYoY
Net product revenues$1.17B90.8%+74.4%
— AMVUTTRA (part of Net product revenues)$1.01B78.4%+105.7%
— GIVLAARI (part of Net product revenues)$89.8M7.0%+11.0%
— Royalty revenue (part of Net product revenues)$71.7M5.6%+79.3%
Total TTR$1.03B79.8%+89.2%
Total Rare$141.9M11.0%+11.1%
OXLUMO$52.1M4.0%+11.2%
Net revenues from collaborations$47.2M3.7%-23.3%
ONPATTRO$18.5M1.4%-64.9%
Total revenue$1.29B100%—

As tagged by the company in its SEC 10-Q / 10-K filings (XBRL).

ALNY suppliers, customers and competitors (named in its 10-K)

RelationshipCompanySentence in the filing
SupplierAGILENT TECHNOLOGIES, INC. (A)“In 2020, we amended our commercial supply agreement with Agilent to provide for Agilent to supply, subject to any conflicting obligations under our third-party agreements, a specified percentage of the API for certain of our commercial products.”
PartnerREGENERON PHARMACEUTICALS, INC. (REGN)“Our collaborator, Regeneron Pharmaceuticals, Inc., or Regeneron, is advancing cemdisiran in combination with its anti-C5 monoclonal antibody, pozelimab, in a Phase 3 clinical trial”
PartnerNOVARTIS AG (NVS)“Leqvio (inclisiran) is being developed and commercialized by our collaborator Novartis AG, or Novartis, and has received marketing authorization from the European Commission, or EC, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia and from the FDA as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia, or H…”
PartnerSanofi (SNY)“Qfitlia (fitusiran) is being commercialized by our collaborator, Genzyme Corporation, a Sanofi Company, or Sanofi, and was approved by the FDA in March 2025 for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with hemophilia A or B, with or without factor VIII or IX inhibitors (neutralizing antibodies), and by China's National Me…”
PartnerVir Biotechnology, Inc. (VIR)“Elebsiran (formerly ALN-HBV02 (VIR-2218)) is a subcutaneously administered, investigational RNAi therapeutic targeting the HBV genome for the treatment of chronic hepatitis delta, or CHD, which is being advanced by our collaborator, Vir Biotechnology, Inc., or Vir.”
PartnerIONIS PHARMACEUTICALS INC (IONS)“Ionis Pharmaceuticals, Inc. In January 2015, we and Ionis Pharmaceuticals, Inc., or Ionis, entered into a second amended and restated strategic collaboration and license agreement, which we further amended in July 2015, or the 2015 Ionis agreement.”
PartnerPeptiDream“In addition, we are exploring peptide and antibody-based approaches for targeted siRNA delivery to new tissues, including as part of our collaboration with PeptiDream, Inc., which aims to discover and develop novel conjugates for targeted delivery of RNAi therapeutics to a broader range of tissues.”
PartnerADARx Pharmaceuticals, Inc. (ADRX)“Companies working on chemically synthesized siRNAs include but are not limited to ADARx Pharmaceuticals, Inc., or ADARx, Amgen Inc., Argo Biopharmaceutical Co., Ltd., or Argo, Aro Biotherapeutics, Arrowhead Pharmaceuticals, Inc., or Arrowhead, AstraZeneca plc, or AstraZeneca, Dyne Therapeutics, Inc., Eli Lilly and Company, GlaxoSmithKline plc, Novartis, Novo Nordisk A/S, or Novo Nordisk, SanegeneBio, Sarepta Thera…”
PartnerNovo Nordisk (NVO)“Companies working on chemically synthesized siRNAs include but are not limited to ADARx Pharmaceuticals, Inc., or ADARx, Amgen Inc., Argo Biopharmaceutical Co., Ltd., or Argo, Aro Biotherapeutics, Arrowhead Pharmaceuticals, Inc., or Arrowhead, AstraZeneca plc, or AstraZeneca, Dyne Therapeutics, Inc., Eli Lilly and Company, GlaxoSmithKline plc, Novartis, Novo Nordisk A/S, or Novo Nordisk, SanegeneBio, Sarepta Thera…”
PartnerHoffmann-La Roche“Hoffmann-La Roche Ltd. and Genentech, Inc. or, collectively, Roche, pursuant to which we established a worldwide, strategic collaboration for the joint development and commercialization of zilebesiran.”
PartnerGenentech“Hoffmann-La Roche Ltd. and Genentech, Inc. or, collectively, Roche, pursuant to which we established a worldwide, strategic collaboration for the joint development and commercialization of zilebesiran.”
PartnerAMGEN INC (AMGN)“Companies working on chemically synthesized siRNAs include but are not limited to ADARx Pharmaceuticals, Inc., or ADARx, Amgen Inc., Argo Biopharmaceutical Co., Ltd., or Argo, Aro Biotherapeutics, Arrowhead Pharmaceuticals, Inc., or Arrowhead, AstraZeneca plc, or AstraZeneca, Dyne Therapeutics, Inc., Eli Lilly and Company, GlaxoSmithKline plc, Novartis, Novo Nordisk A/S, or Novo Nordisk, SanegeneBio, Sarepta Thera…”
PartnerArgo Biopharmaceutical“Companies working on chemically synthesized siRNAs include but are not limited to ADARx Pharmaceuticals, Inc., or ADARx, Amgen Inc., Argo Biopharmaceutical Co., Ltd., or Argo, Aro Biotherapeutics, Arrowhead Pharmaceuticals, Inc., or Arrowhead, AstraZeneca plc, or AstraZeneca, Dyne Therapeutics, Inc., Eli Lilly and Company, GlaxoSmithKline plc, Novartis, Novo Nordisk A/S, or Novo Nordisk, SanegeneBio, Sarepta Thera…”
CompetitorPfizer (PFE)“For example, AMVUTTRA is administered through a subcutaneous injection and may not compete favorably with other available options for the treatment of ATTR-CM, including VYNDAQEL/VYNDAMAX, which is marketed by Pfizer and administered in pill form, and ATTRUBY, which is marketed by BridgeBio and administered in pill form, or other available options for the treatment of hATTR-PN in adults, including WAINUA, which is…”

Quoted from the company's 10-K filed Feb 12, 2026.

Companies that name ALNY in their SEC reports

Relationship to ALNYCompanyFilingSentence
partnerArbutus Biopharma Corp (ABUS)10-K Mar 23, 2026“In 2012, we entered into a license agreement with Alnylam that entitles Alnylam to develop and commercialize products with our LNP technology in exchange for milestone and royalty payments.”
supplierVEEVA SYSTEMS INC (VEEV)10-K Mar 20, 2026“Our life sciences customers range from the largest global pharmaceutical and biotechnology companies such as Bayer AG, Boehringer Ingelheim GmbH, Eli Lilly and Company, Gilead Sciences, Inc., Merck Sharp & Dohme Corp., and Novartis Pharma AG, to emerging growth pharmaceutical and biotechnology companies, including Alkermes Inc., Alnylam Pharmaceuticals, Inc., bluebird bio, Inc., and Idorsia Pharmaceuticals Ltd. We…”
partnerTenaya Therapeutics, Inc. (TNYA)10-K Mar 11, 2026“our collaboration with Alnylam, including potential targets, research and development strategy, the timing and duration of the collaboration, expected payments, and the achievement of milestones;”
partnerVir Biotechnology, Inc. (VIR)10-K Feb 23, 2026“Collaboration and License Agreement with Alnylam”
partnerKrystal Biotech, Inc. (KRYS)10-K Feb 17, 2026“•Gene Silencing Approaches: We are aware of two companies, Takeda Pharmaceutical Company Limited (in partnership with Arrowhead Pharmaceutical Inc.) and Novo Nordisk A/S (in partnership with Alnylam Pharmaceuticals, Inc.), which are developing interfering RNA medicines to treat the liver manifestations of AATD.”
partnerAGIOS PHARMACEUTICALS, INC. (AGIO)10-K Feb 12, 2026“•the amount and timing of future milestone and royalty payments potentially payable to Alnylam Pharmaceuticals, Inc. pursuant to the license agreement entered into in July 2023;”
partnerREGENERON PHARMACEUTICALS, INC. (REGN)10-K Feb 4, 2026“See the "Collaboration, License, and Other Agreements" section below for descriptions of our agreements with Alnylam Pharmaceuticals, Inc. and Intellia Therapeutics, Inc.”
partnerNOVARTIS AG (NVS)20-F Feb 4, 2026“Novartis obtained global rights to develop, manufacture and commercialize Leqvio under a license and collaboration agreement with Alnylam Pharmaceuticals, Inc.”
partnerARROWHEAD PHARMACEUTICALS, INC. (ARWR)10-K Nov 25, 2025“Pursuant to this acquisition, Roche assigned to the Company its entire rights under certain licenses including: the License and Collaboration Agreement between Roche and Alnylam dated July 8, 2007; the Non-Exclusive Patent License Agreement between Roche and MDRNA, Inc. dated February 12, 2009 ("MDRNA License"); and the Non-Exclusive License Agreement between Roche and City of Hope dated September 19, 2011 (collec…”

ALNY company outlook (results filed Jul 30, 2026)

Quoted word-for-word from the SEC 8-K results press release.

ALNY analyst estimates and revisions

PeriodEPS estimate90 days agoChangeRevenue estimateAnalysts
Current quarter (ends Sep 2026)$2.25$2.41-6.7%$1.43B14
Next quarter (ends Dec 2026)$2.85$2.89-1.6%$1.57B13
Current fiscal year (ends Dec 2026)$8.86$9.42-5.9%$5.48B14
Next fiscal year (ends Dec 2027)$12.36$13.44-8.1%$6.89B13

ALNY options: expected move

Options price a move of about ±14.4% (±$32.80) by Nov 20, 2026, which includes earnings on Oct 29, 2026. Over the last 8 reports the stock moved ±9.3% on average.

ExpirationDaysATM implied volatilityExpected move
Nov 20, 20262863.7%±14.4%
Dec 18, 20265657.2%±18.1%
Jan 15, 20278455.9%±21.6%
Mar 19, 202714756.6%±28.7%
Jun 17, 202723755.4%±35.5%
Sep 17, 202732954.5%±40.9%

30-day implied volatility 62.5% vs 40.5% realized over the last 30 trading days. Put/call ratio (volume) 1.87. Cboe delayed quotes (15 min). Expected move = at-the-money straddle.

Key Statistics (as of October 23, 2026 at 15:07 UTC)

PriceUSD 223.24
Change▼ 1.78% (down)
Previous CloseUSD 227.28
OpenUSD 227.28
Day RangeUSD 222 – 227.28
52-Week RangeUSD 197.81 – 485.36
Volume239,900 shares
Market Cap$29.87B
ExchangeNMS

Technical Analysis (ALNY)

Nexqual's technical model rates ALNY "STRONG SELL" based on 0 bullish and 5 bearish signals across 128 daily candles, as of October 23, 2026 at 15:07 UTC.

Overall SignalSTRONG SELL
RSI (14)38.41 (neutral)
vs SMA50Below (USD 239.04)
MACD-4.25 (negative)

Analyst Ratings (ALNY)

Wall Street analysts rate ALNY "Buy" based on 30 analysts, with a mean price target of USD 368.7 (range USD 250–536), per Nexqual as of October 23, 2026 at 15:07 UTC.

Consensus RatingBuy
Analyst Count30
Mean TargetUSD 368.7
High TargetUSD 536
Low TargetUSD 250
Buy / Hold / Sell23 / 7 / 0

Earnings (ALNY)

Next Earnings Date2026-10-29
EPS EstimateUSD 2.25
Revenue Estimate$1.43B

Recent Earnings History

QuarterActual vs Estimate
2026-06-30USD 1.84 vs est 2.14 ▼ miss
2026-03-31USD 1.99 vs est 1.47 ▲ beat
2025-12-31USD 1.25 vs est 1.5 ▼ miss
2025-09-30USD 2.9 vs est 1.75 ▲ beat

Source: Nexqual, October 23, 2026 at 15:07 UTC.

Financials & Fundamentals (ALNY)

Total Revenue$4.80B
Revenue Growth (latest quarter, YoY)+66.90%
Gross Margin+79.65%
Operating Margin+17.93%
Profit Margin+16.13%
ROE+96.56%
Debt / Equity2.21
Current Ratio3.06
Total Cash$3.31B
Total Debt$2.99B
Free Cash Flow (fiscal year ended Dec 2025, SEC 10-K)$465.38M (12.5% of revenue)

Source: Nexqual, October 23, 2026 at 15:07 UTC.

Financial Health Score (ALNY)

Nexqual rates Alnylam Pharmaceuticals, Inc.'s overall financial health "Solid" across five dimensions, as of October 23, 2026 at 15:07 UTC.

GrowthStrong — Revenue +65% YoY (annual)
ProfitabilityStrong — Gross margin 80%, operating 18% (last 12 months)
Balance SheetWeak — $3.31B cash and investments vs $1.01B debt (Jun 2026, SEC), net cash
Cash FlowSolid — FCF $465M (FY ended Dec 2025, 10-K), 13% margin
EfficiencyStrong — ROE 97%, ROA 12.3%

Ownership (ALNY)

Insider Ownership+0.18%
Institutional Ownership+101.54%
Shares Outstanding133.81M
Float133.22M
Short % of Float+7.68%

Source: Nexqual, October 23, 2026 at 15:07 UTC.

Leadership (ALNY)

Alnylam Pharmaceuticals, Inc. is led by Yvonne L. Greenstreet, CEO & Director, per Nexqual as of October 23, 2026 at 15:07 UTC.

CEO & DirectorYvonne L. Greenstreet
CFO & Executive VPJeffrey V. Poulton
Executive VP, Chief Scientific Officer and Head of Early Research & Early DevelopmentKevin Joseph Fitzgerald
Vice President of Investor RelationsJoshua Brodsky

Major Backers & Investors (ALNY)

Notable institutional backers of Alnylam Pharmaceuticals, Inc. include Capital Group, FMR, LLC, Growth Fund of America, according to Nexqual as of October 23, 2026 at 15:07 UTC.

Active Investors

InvestorStake
Capital Group15.62%
FMR, LLC11.23%
Growth Fund of America6.7%
T. Rowe Price4.22%
Amcap Fund3.38%
Invesco2.81%
JPMorgan2%

Index Funds (Passive)

FundStake
Vanguard Group9.4%
BlackRock8.15%
State Street2.66%

Source: Nexqual, October 23, 2026 at 15:07 UTC.

From Alnylam Pharmaceuticals, Inc.'s Latest SEC 10-K Filing (filed 2026-02-12)

Key Strengths & Strategy (as disclosed to the SEC)

Partnerships

Legal & Regulatory Risks (Item 1A, quoted)

Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.

Peers & Related Stocks

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GMABGenmab A/SUSD 39.67▼ 0.82%
INCYIncyte CorporationUSD 115.4▼ 1.31%
RVMDRevolution Medicines, Inc.USD 187.18▼ 0.27%
BNTXBioNTech SEUSD 88.1▼ 1.75%

Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 23, 2026 at 15:07 UTC. This page is informational and not investment advice.

For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt