Avalo Therapeutics, Inc. (AVTX) Stock Price & Analysis
Avalo Therapeutics, Inc. (AVTX) closed at USD 7.12 on Wednesday, October 28, 2026, up 5.48% on the day. The US market is currently closed; this is not a live price.
The prior close was USD 6.75; the Oct 28, 2026 session ranged USD 6.66–7.14 on volume of 2,165,697 shares. Market capitalization is $381.85M, with a 52-week range of USD 6.53–24.27 (NCM). Source: Nexqual, retrieved October 29, 2026 at 07:20 UTC.
Also available as compact Markdown for AI agents: nexqual.com/AVTX.md
Key facts (AVTX)
- Analysts: Buy (mean 2.00 on a 1–5 scale) (14 analysts), mean target USD 36.6 (range 10–60).
- Total return with dividends: 1Y -60.5% vs S&P 500 +13.6%; 5Y -99.9% vs S&P 500 +79.8%.
- Next earnings: 2026-11-12, EPS estimate USD -0.55, revenue estimate $0K.
Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (AVTX)
| USD | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 | TTM |
|---|---|---|---|---|---|---|
| Revenue | $5.4M | $18.1M | $1.9M | $441K | $59K | — |
| Gross profit | $3.9M | $14.6M | $640K | — | — | — |
| Operating income | -$82.1M | -$37.4M | -$27.4M | -$68.5M | -$72.9M | -$91.4M |
| Net income | -$84.4M | -$41.7M | -$31.5M | -$35.1M | -$78.3M | -$100M |
| EPS (diluted) | — | -$1063.00 | -$113.58 | -$20.91 | -$5.84 | — |
| Free cash flow | -$71.0M | -$26.8M | -$30.8M | -$49.1M | — | — |
| Gross margin | 72.4% | 81.0% | 33.3% | — | — | — |
| Operating margin | -1521.6% | -207.4% | -1421.6% | -15535.6% | -123601.7% | — |
| Net margin | -1563.1% | -230.8% | -1639.5% | -7965.8% | -132642.4% | — |
| Revenue growth | -19.4% | +234.4% | -89.3% | -77.1% | -86.6% | — |
| Cash + short-term investments | $54.6M | $13.2M | $7.4M | $135M | $98.3M | — |
| Total debt | $32.8M | $13.5M | $0K | — | — | — |
Fiscal years end Dec. EPS is split-adjusted.
Valuation (price ÷ last four quarters, through Jun 30, 2026) (AVTX)
P/B 0.8x · Earnings yield -26.28%
Analysts (AVTX)
Consensus Buy (mean 2.00 on a 1–5 scale), 14 analysts; mean target USD 36.6 (low 10, high 60).
Rating changes, last 120 days:
| Date | Firm | Action | Rating | Price target |
|---|---|---|---|---|
| 2026-10-23 | Guggenheim | Downgrade | Buy → Neutral | |
| 2026-10-23 | Wedbush | Target lowered | Outperform | $34 → $22 |
| 2026-10-23 | HC Wainwright & Co. | Downgrade | Buy → Neutral | |
| 2026-10-23 | BTIG | Target lowered | Buy | $58 → $10 |
| 2026-08-07 | Guggenheim | Target lowered | Buy | $50 → $48 |
| 2026-08-07 | HC Wainwright & Co. | Target lowered | Buy | $35 → $30 |
| 2026-07-06 | Leerink Partners | Initiated | Outperform | $38 |
Total return (dividends reinvested) (AVTX)
| 1Y (from 2025-10-29) | 5Y (from 2021-10-25) | |
|---|---|---|
| Total return | -60.5% | -99.9% |
| S&P 500 (SPY) | +13.6% | +79.8% |
| Per year | -60.7% | -74.5% |
| Volatility (annualized) | 92.7% | 169.6% |
| Max drawdown | -70.5% (May 2026→Oct 2026) | -100.0% (Nov 2021→May 2025) |
AVTX earnings history and stock reaction
| Results filed | Quarter | EPS | Consensus | Surprise | Stock reaction |
|---|---|---|---|---|---|
| Aug 6, 2026 | Quarter ended Jun 30, 2026 | −$0.83 | −$0.62 | Miss −33.9% | -2.8% |
| May 13, 2026 | Quarter ended Mar 31, 2026 | −$0.98 | −$1.07 | Beat +8.4% | -4.7% |
| May 7, 2026 | Quarter ended Mar 31, 2026 | −$0.98 | −$1.07 | Beat +8.4% | -1.1% |
| Mar 23, 2026 | Quarter ended Dec 31, 2025 | −$0.37 | −$1.49 | Beat +75.2% | +0.2% |
| Jan 12, 2026 | Quarter ended Dec 31, 2025 | −$0.37 | −$1.49 | Beat +75.2% | +1.5% |
| Nov 6, 2025 | Quarter ended Sep 30, 2025 | −$2.19 | −$1.64 | Miss −33.5% | -8.5% |
| Aug 7, 2025 | — | — | — | — | +7.5% |
| May 12, 2025 | — | — | — | — | -9.4% |
EPS as reported against the analyst consensus before the release; surprise uses the cent-rounded figures shown (in dollars when EPS and consensus have opposite signs). Stock reaction = close before the results to close after (the first close following a release after the bell or before the open).
AVTX recent SEC filings (last 120 days)
| Filed | Form | What it says |
|---|---|---|
| Aug 14, 2026 | Schedule 13G/A | Nantahala Capital Management, LLC, Wilmot B. Harkey: 3.5% of shares, passive 5%+ holder (amended) |
| Aug 14, 2026 | Schedule 13G/A | Caligan Partners LP, David Johnson: 5.9% of shares, passive 5%+ holder (amended) |
| Aug 14, 2026 | Schedule 13G/A | RA Capital Management, L.P., Peter Kolchinsky: 6.3% of shares, passive 5%+ holder (amended) |
| Aug 14, 2026 | Schedule 13G/A | BIOTECHNOLOGY VALUE FUND L P, BVF I GP LLC: 5.3% of shares, passive 5%+ holder (amended) |
| Aug 14, 2026 | Schedule 13G/A | T. Rowe Price Investment Management, Inc.: 0.0% of shares, passive 5%+ holder (amended) |
| Aug 14, 2026 | Schedule 13G/A | Avoro Capital Advisors LLC, Behzad Aghazadeh: 4.4% of shares, passive 5%+ holder (amended) |
| Aug 14, 2026 | Schedule 13G/A | Deep Track Capital, LP, Deep Track Biotechnology Master Fund, Ltd.: 6.9% of shares, passive 5%+ holder (amended) |
| Aug 13, 2026 | Schedule 13G/A | Affinity Asset Advisors, LLC, Michael Cho: 5.5% of shares, passive 5%+ holder (amended) |
| Aug 7, 2026 | Schedule 13G/A | passive 5%+ holder (amended) |
| Aug 7, 2026 | Schedule 13G | passive 5%+ holder |
| Aug 6, 2026 | Schedule 13G/A | passive 5%+ holder (amended) |
| Aug 6, 2026 | 10-Q | Quarterly report · period ended Jun 30, 2026 |
| Aug 6, 2026 | 8-K | Quarterly results |
| Jul 27, 2026 | Schedule 13G | passive 5%+ holder |
Source: SEC EDGAR. Quotes are the opening words of each item as filed; each form links to the filing. Insider Form 4 filings are listed in the insider sections.
AVTX suppliers, customers and competitors (named in its 10-K)
| Relationship | Company | Sentence in the filing |
|---|---|---|
| Customer | ES Therapeutics | “In the event that J&J and/or Apollo are required to make payment(s) to ES Therapeutics pursuant to the underlying agreements, we will recognize revenue under our existing contracts with those customers for that amount when it is no longer probable there would be a significant revenue reversal with any differences between the fair value of the derivative liability related to that payment immediately prior to the re…” |
| Customer | Apollo AP43 | “In the event that J&J and/or Apollo are required to make payment(s) to ES Therapeutics pursuant to the underlying agreements, we will recognize revenue under our existing contracts with those customers for that amount when it is no longer probable there would be a significant revenue reversal with any differences between the fair value of the derivative liability related to that payment immediately prior to the re…” |
| Partner | Eli Lilly (LLY) | “Eli Lilly License Agreement” |
| Partner | Johnson & Johnson (JNJ) | “The economic rights sold include (a) rights to a milestone payment of $20.0 million upon the filing and acceptance of an NDA for AVTX-501 pursuant to an agreement with Janssen Pharmaceutics, Inc., now Johnson & Johnson Innovative Medicine ("J&J") (the "AVTX-501 Milestone") and (b) rights to any future milestone payments and royalties relating to AVTX-007 under a license agreement with Apollo AP43 Limited ("Apollo"…” |
| Partner | Leap Therapeutics | “We have not paid any milestones, royalties or any other amounts under the Lilly License Agreement or the Leap Agreement as of the date of this report.” |
| Partner | Apple (AAPL) | “From September 2012 to September 2013, Dr. Neil was a Partner at Apple Tree Partners, a life sciences private equity fund.” |
| Partner | Kyowa Kirin | “Under the KKC License Agreement, the Company paid KKC an upfront license fee of $10.0 million, which we recognized within research and development expenses in 2021.” |
| Partner | Alto Neuroscience, Inc. (ANRO) | “Under the out-license agreement, the Company received a mid-six digit upfront payment from Alto, which we recognized as license revenue in 2021.” |
| Competitor | AbbVie (ABBV) | “There are numerous other companies that have commercialized or are developing treatments for HS and inflammatory diseases that we will compete with, including AbbVie, Lilly, Merck, Novartis, Pfizer, Sanofi, Takeda, UCB and others.” |
| Competitor | Merck (MRK) | “There are numerous other companies that have commercialized or are developing treatments for HS and inflammatory diseases that we will compete with, including AbbVie, Lilly, Merck, Novartis, Pfizer, Sanofi, Takeda, UCB and others.” |
| Competitor | Pfizer (PFE) | “There are numerous other companies that have commercialized or are developing treatments for HS and inflammatory diseases that we will compete with, including AbbVie, Lilly, Merck, Novartis, Pfizer, Sanofi, Takeda, UCB and others.” |
Quoted from the company's 10-K filed Mar 23, 2026.
Companies that name AVTX in their SEC reports
| Relationship to AVTX | Company | Filing | Sentence |
|---|---|---|---|
| partner | Alto Neuroscience, Inc. (ANRO) | 10-K Mar 16, 2026 | “In May 2021, we entered into a patent and know-how license agreement, or the Cerecor Agreement, with Cerecor Inc. (n/k/a Avalo Therapeutics, Inc.), or Cerecor, pursuant to which we obtained an exclusive worldwide, royalty-bearing license, with the right to sublicense, under certain patent rights and know-how owned or controlled by Cerecor relating to an NR2B inhibitor compound now known as ALTO-202, including cert…” |
AVTX company outlook (results filed Aug 6, 2026)
- “The Company expects to submit an Investigational New Drug (IND) application in the first half of 2027. • Appointed Ron Philip to its Board of Directors.”
Quoted word-for-word from the SEC 8-K results press release.
AVTX analyst estimates and revisions
| Period | EPS estimate | 90 days ago | Change | Revenue estimate | Analysts |
|---|---|---|---|---|---|
| Current quarter (ends Sep 2026) | $-0.55 | $-0.55 | $0.00 | $0 | 8 |
| Next quarter (ends Dec 2026) | $-0.53 | $-0.66 | +$0.13 | $0 | 8 |
| Current fiscal year (ends Dec 2026) | $-2.72 | $-2.56 | −$0.16 | $0 | 8 |
| Next fiscal year (ends Dec 2027) | $-2.78 | $-2.76 | −$0.01 | $0 | 10 |
AVTX options: expected move
Options price a move of about ±44.2% (±$3.15) by Nov 20, 2026, which includes earnings on Nov 12, 2026. Over the last 8 reports the stock moved ±4.5% on average.
| Expiration | Days | ATM implied volatility | Expected move |
|---|---|---|---|
| Nov 20, 2026 | 23 | 206.9% | ±44.2% |
| Dec 18, 2026 | 51 | 80.5% | ±24.9% |
| Feb 19, 2027 | 114 | 99.0% | ±44.2% |
| May 21, 2027 | 205 | 92.2% | ±54.4% |
30-day implied volatility 76.5% vs 153.1% realized over the last 30 trading days. Put/call ratio (volume) 3.68. Cboe delayed quotes (15 min). Expected move = at-the-money straddle.
Key Statistics (as of October 29, 2026 at 07:20 UTC)
| Price | USD 7.12 |
|---|---|
| Change | ▲ 5.48% (up) |
| Previous Close | USD 6.75 |
| Open | USD 6.66 |
| Day Range | USD 6.66 – 7.14 |
| 52-Week Range | USD 6.53 – 24.27 |
| Volume | 2,165,697 shares |
| Market Cap | $381.85M |
| Exchange | NCM |
Technical Analysis (AVTX)
Nexqual's technical model rates AVTX "SELL" based on 2 bullish and 5 bearish signals across 127 daily candles, as of October 29, 2026 at 07:20 UTC.
| Overall Signal | SELL |
|---|---|
| RSI (14) | 20.44 (oversold) |
| vs SMA50 | Below (USD 15.29) |
| MACD | -2.33 (negative) |
Analyst Ratings (AVTX)
Wall Street analysts rate AVTX "Buy" based on 14 analysts, with a mean price target of USD 36.6 (range USD 10–60), per Nexqual as of October 29, 2026 at 07:20 UTC.
| Consensus Rating | Buy |
|---|---|
| Analyst Count | 14 |
| Mean Target | USD 36.6 |
| High Target | USD 60 |
| Low Target | USD 10 |
| Buy / Hold / Sell | 12 / 2 / 0 |
Earnings (AVTX)
| Next Earnings Date | 2026-11-12 |
|---|---|
| EPS Estimate | USD -0.55 |
| Revenue Estimate | $0 |
Recent Earnings History
| Quarter | Actual vs Estimate |
|---|---|
| 2026-06-30 | USD -0.83 vs est -0.62 ▼ miss |
| 2026-03-31 | USD -0.98 vs est -1.07 ▲ beat |
| 2025-12-31 | USD -0.37 vs est -1.5 ▲ beat |
| 2025-09-30 | USD -2.19 vs est -1.64 ▼ miss |
Source: Nexqual, October 29, 2026 at 07:20 UTC.
Financials & Fundamentals (AVTX)
| Total Revenue | $59,000 |
|---|---|
| Gross Margin | +0.00% |
| Operating Margin | -154847.45% |
| Profit Margin | +0.00% |
| ROE | -36.27% |
| Debt / Equity | 0 |
| Current Ratio | 19.31 |
| Total Cash | $400.28M |
| Total Debt | $242,000 |
Source: Nexqual, October 29, 2026 at 07:20 UTC.
Financial Health Score (AVTX)
Nexqual rates Avalo Therapeutics, Inc.'s overall financial health "Weak" across five dimensions, as of October 29, 2026 at 07:20 UTC.
| Growth | Critical — Revenue -87% YoY (annual), sharp decline |
|---|---|
| Profitability | Critical — Heavily loss-making — early-stage company |
| Balance Sheet | Strong — $400M cash, no debt |
| Cash Flow | Weak — Operating cash flow -$51M (FY ended Dec 2025, 10-K) |
| Efficiency | Critical — ROE -22%, ROA -20.4% (last 4 quarters, SEC) |
Ownership (AVTX)
| Insider Ownership | +1.69% |
|---|---|
| Institutional Ownership | +133.64% |
| Shares Outstanding | 53.63M |
| Float | 40.11M |
| Short % of Float | +22.34% |
Source: Nexqual, October 29, 2026 at 07:20 UTC.
Leadership (AVTX)
Avalo Therapeutics, Inc. is led by Garry A. Neil, President, CEO & Director, per Nexqual as of October 29, 2026 at 07:20 UTC.
| President, CEO & Director | Garry A. Neil |
|---|---|
| Founder and Chairman of Scientific Advisory Board | Solomon H. Snyder |
| CFO & Head of Investor relations | Christopher Ryan Sullivan |
| Senior Vice President of Human Resources | Ashley Ivanowicz |
| Senior Vice President of CMC & Technical Operations | Dino C. Miano |
Major Backers & Investors (AVTX)
Notable institutional backers of Avalo Therapeutics, Inc. include FMR, LLC, Deep Track Capital, Lp, Caligan Partners, LP, according to Nexqual as of October 29, 2026 at 07:20 UTC.
Active Investors
| Investor | Stake |
|---|---|
| FMR, LLC | 9.51% |
| Deep Track Capital, Lp | 6.73% |
| Caligan Partners, LP | 5.9% |
| TCG Crossover Management, LLC | 5.63% |
| Fidelity | 5.5% |
| Affinity Asset Advisors, Llc | 5.41% |
| Farallon Capital Management LLC | 4.66% |
| Point72 Asset Management, L.P. | 4.45% |
Index Funds (Passive)
| Fund | Stake |
|---|---|
| BlackRock | 8.14% |
| State Street | 5.39% |
Source: Nexqual, October 29, 2026 at 07:20 UTC.
From Avalo Therapeutics, Inc.'s Latest SEC 10-K Filing (filed 2026-03-23)
Key Strengths & Strategy (as disclosed to the SEC)
- In the United States, the FDA regulates biologics under the Federal Food, Drug, and Cosmetic Act ("FDCA"), the Public Health Service Act, and its implementing regulations.
- State and foreign laws, including for example the European Union General Data Protection Regulation, which became effective May 2018 also govern the privacy and security of health information in some circumstances, many of which differ from each other in significant ways and often are not preempted by HIPAA, thus complicating compliance efforts.
- Our success depends in part on our ability to obtain and maintain proprietary protection for the technology and know-how upon which our product candidates are based, to operate without infringing the proprietary rights of third parties and to prevent third parties from infringing our proprietary rights.
- We also rely on trade secrets and proprietary know-how, including manufacturing and formulation know-how, as well as confidentiality agreements and other contractual protections, to protect aspects of our technology and product candidates that may not be patentable or that we elect not to patent.
Partnerships
- We are required to pay Lilly up to $70 million based on the achievement of specified development and regulatory milestones.
- Upon commercialization, we are required to pay sales-based milestones aggregating up to $650 million payable to Lilly and up to $70 million to Leap.
Legal & Regulatory Risks (Item 1A, quoted)
- The FDA may refuse to accept any application for filing, may place a clinical hold on a clinical trial at any stage, or may decide that our data are insufficient for approval and require additional preclinical, clinical or other studies.
- The FDA or other regulatory authority may require more information, including additional preclinical or clinical studies to support approval, which may delay or prevent approval and our commercialization plans, or we may decide to abandon the development program.
- We are conducting clinical trials for abdakibart (AVTX-009) at sites in foreign jurisdictions, and the FDA might not accept data from trials conducted in such locations.
- We may fail to achieve our development and regulatory milestones on expected timelines, or at all, which could materially and adversely affect our business, financial condition, results of operations and prospects.
Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.
Peers & Related Stocks
| Symbol | Name | Price | Change |
|---|---|---|---|
| ORKA | Oruka Therapeutics, Inc. | USD 95.97 | ▲ 0.17% |
| LGND | Ligand Pharmaceuticals Incorpor | USD 318.78 | ▲ 2.26% |
| IOVA | Iovance Biotherapeutics, Inc. | USD 14.81 | ▲ 1.58% |
| IONS | Ionis Pharmaceuticals, Inc. | USD 44.9 | ▲ 2.14% |
| AXSM | Axsome Therapeutics, Inc. | USD 143.51 | ▲ 0.92% |
| ABVX | Abivax SA | USD 89.84 | ▲ 3.26% |
Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 29, 2026 at 07:20 UTC. This page is informational and not investment advice.
For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt