4D Molecular Therapeutics, Inc. (FDMT) Stock Price & Analysis

4D Molecular Therapeutics, Inc. (FDMT) closed at USD 12.78 on Thursday, October 29, 2026, down 1.16% on the day. The US market is currently closed (after-hours); this is not a live price.

The prior close was USD 12.93; the Oct 29, 2026 session ranged USD 12.57–13.46 on volume of 848,889 shares. Market capitalization is $706.02M, with a 52-week range of USD 6.96–16.93 (NMS). Source: Nexqual, retrieved October 29, 2026 at 21:08 UTC.

Also available as compact Markdown for AI agents: nexqual.com/FDMT.md

Key facts (FDMT)

Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (FDMT)

USDFY2021FY2022FY2023FY2024FY2025TTM
Revenue$18.0M$3.1M$20.7M$37K$85.2M$92.0M
Operating income-$71.3M-$110M-$113M-$188M-$160M-$197M
Net income-$71.3M-$107M-$101M-$161M-$140M-$179M
EPS (diluted)-$2.57-$3.32-$2.58-$2.98-$2.42—
Free cash flow-$78.2M-$98.2M-$78.6M-$138M-$110M—
Operating margin-395.5%-3516.5%-544.6%-507678.4%-187.2%-214.2%
Net margin-395.4%-3435.4%-486.6%-434778.4%-164.4%-194.7%
Revenue growth+32.5%-82.7%+562.3%-99.8%+230194.6%—
Cash + short-term investments$248M$214M$288M$425M$514M—
Total debt————$0K—

Fiscal years end Dec. EPS is split-adjusted.

Valuation (price ÷ last four quarters, through Jun 30, 2026) (FDMT)

P/S 7.7x · EV/Sales 4.0x · P/B 1.7x · Earnings yield -25.38% · Net cash $342M · EV $364M

Insider sales (SEC Form 4, open-market, last ~7 months) (FDMT)

14 of 14 under a Rule 10b5-1 trading plan (scheduled in advance). Unplanned sales were timed by the insider.

Trade dateInsiderRoleSharesValue% of holdings sold10b5-1 planInsider type
2026-10-16Bizily ScottChief Legal Officer1,635$21K15.9%Yes (adopted January 13, 2026)Opportunistic (traded every year 2023–2025, no repeating month)
2026-10-05Kirn DavidSee Remarks58,333$754K7.6%Yes (adopted January 9, 2026)Too little history (no open-market trades in 2025)
2026-09-16Bizily ScottChief Legal Officer1,635$22K15.9%Yes (adopted January 13, 2026)Opportunistic (traded every year 2023–2025, no repeating month)
2026-09-14Kirn DavidSee Remarks58,333$811K7.1%Yes (adopted January 9, 2026)Too little history (no open-market trades in 2025)
2026-09-01Bizily ScottChief Legal Officer584$8K6.3%Yes (adopted January 13, 2026)Opportunistic (traded every year 2023–2025, no repeating month)
2026-08-19Kirn DavidSee Remarks69,076$1.1M7.7%Yes (adopted January 9, 2026)Too little history (no open-market trades in 2025)
2026-08-13…2026-08-17Bizily ScottChief Legal Officer3,270$40K27.5%Yes (adopted January 13, 2026)Opportunistic (traded every year 2023–2025, no repeating month)
2026-08-04Kirn DavidSee Remarks26,842$275K3.1%Yes (adopted January 9, 2026)Too little history (no open-market trades in 2025)
2026-08-03Kirn DavidSee Remarks12,415$125K1.4%Yes (adopted January 9, 2026)Too little history (no open-market trades in 2025)
2026-07-09…2026-07-10Kirn DavidSee Remarks58,333$737K6.2%Yes (adopted January 9, 2026)Too little history (no open-market trades in 2025)
2026-06-30Bizily ScottChief Legal Officer6,566$92K43.2%Yes (adopted January 13, 2026)Opportunistic (traded every year 2023–2025, no repeating month)
2026-06-23Bizily ScottChief Legal Officer9,810$118K53.2%YesOpportunistic (traded every year 2023–2025, no repeating month)
2026-06-22Kirn DavidSee Remarks114,746$1.2M10.9%Yes (adopted January 9, 2026)Too little history (no open-market trades in 2025)
2026-06-01Kirn DavidSee Remarks1,922$19K0.2%Yes (adopted January 9, 2026)Too little history (no open-market trades in 2025)

% of holdings sold = shares sold ÷ (shares sold + all holdings the insider reported on that Form 4, direct and through trusts).

Insider type follows Cohen, Malloy & Pomorski (Journal of Finance, 2012). An insider who traded the stock in the same calendar month in each of the past three years is a routine trader; one who traded in each of those years without such a pattern is an opportunistic trader. In their study, trades by opportunistic insiders predicted future returns and trades by routine insiders did not. Counts open-market purchases and sales only (SEC Form 4 codes P and S) by that insider in that company. Not investment advice.

Analysts (FDMT)

Consensus Buy (mean 1.92 on a 1–5 scale), 12 analysts; mean target USD 28.09 (low 18, high 37).

Rating changes, last 120 days:

DateFirmActionRatingPrice target
2026-10-22HC Wainwright & Co.ReiteratedBuy$36
2026-10-06Chardan CapitalTarget loweredBuy$26 → $25
2026-09-29B of A SecuritiesTarget raisedBuy$29 → $33
2026-09-14Cantor FitzgeraldUpgradeNeutral → Overweight$20
2026-07-31B. Riley SecuritiesInitiatedBuy$37
2026-07-20HC Wainwright & Co.ReiteratedBuy$36

Total return (dividends reinvested) (FDMT)

1Y (from 2025-10-30)5Y (from 2021-10-25)
Total return+12.9%-46.8%
S&P 500 (SPY)+14.4%+79.1%
Per year+12.9%-11.8%
Volatility (annualized)76.3%87.0%
Max drawdown-38.3% (Nov 2025→Jan 2026)-92.2% (Mar 2024→Apr 2025)

FDMT earnings history and stock reaction

Results filedQuarterEPSConsensusSurpriseStock reaction
Aug 13, 2026Quarter ended Jun 30, 2026−$1.04−$1.02Miss −2.0%+2.7%
May 7, 2026Quarter ended Mar 31, 2026−$1.01−$1.00Miss −1.0%-2.7%
Mar 18, 2026Quarter ended Dec 31, 2025$0.43−$0.53Beat +$0.96+4.3%
Jan 7, 2026Quarter ended Sep 30, 2025−$1.01−$0.98Miss −3.1%+1.5%
Nov 10, 2025Quarter ended Sep 30, 2025−$1.01−$0.98Miss −3.1%+2.9%
Nov 6, 2025Quarter ended Sep 30, 2025−$1.01−$0.98Miss −3.1%-0.1%
Aug 11, 2025————+9.2%
May 8, 2025————-1.1%

EPS as reported against the analyst consensus before the release; surprise uses the cent-rounded figures shown (in dollars when EPS and consensus have opposite signs). Stock reaction = close before the results to close after (the first close following a release after the bell or before the open).

FDMT recent SEC filings (last 120 days)

FiledFormWhat it says
Sep 28, 20268-KOther material event
“On September 28, 2026, 4D Molecular Therapeutics, Inc. (the "Company") reported that the first patients have been enrolled across multiple sites in the 4SIGHT Phase 3 clinical trial evaluating 4D-150 for the treatment of diabetic macular edema ("DME"). The Company also reported 2-year data from the SPECTRA clinical trial. 4SIGHT: Phase 3 Trial Design and Regulatory Pathway 4SIGHT is a global Phase 3 multicenter, randomized, double-masked, aflibercept 2 mg ("Q8W") comparator-controlled trial of intravitreal 4D-150…”
Aug 13, 202610-QQuarterly report · period ended Jun 30, 2026
Aug 13, 20268-KQuarterly results
Jul 20, 20268-KOther material event
“On July 18, 2026, 4D Molecular Therapeutics, Inc. (the "Company") reported positive 2-year data from the PRISM Phase 2b clinical trial evaluating 4D-150 in a broad wet age-related macular degeneration ("wet AMD") population. 2-Year Data from PRISM Phase 2b Clinical Trial (Data Cutoff May 18, 2026): Trial and Patient Cohort Overview The Phase 2b trial enrolled 45 patients at two dose levels of a single intravitreal dose of 4D-150 (3E10 and 1E10 vg/eye); 3E10 vg/eye was chosen as the dose for the 4FRONT Phase 3…”

Source: SEC EDGAR. Quotes are the opening words of each item as filed; each form links to the filing. Insider Form 4 filings are listed in the insider sections.

FDMT suppliers, customers and competitors (named in its 10-K)

RelationshipCompanySentence in the filing
PartnerOtsuka Pharmaceutical“the expected potential benefits of strategic collaboration agreements, including our relationships with Otsuka Pharmaceutical Co., Ltd. and Cystic Fibrosis Foundation, and our ability to attract collaborators with development, regulatory and commercialization expertise;”
PartnerAMD (AMD)“On October 31, 2025, we entered into a Collaboration and License Agreement ("Otsuka Collaboration and License Agreement") with Otsuka Pharmaceutical Co., Ltd. ("Otsuka"), pursuant to which we granted Otsuka exclusive rights to develop and commercialize 4D-150 for retinal vascular diseases, including wet AMD and DME, in Japan, China, Australia, and other Asia-Pacific ("APAC") markets.”
PartnerAstellas Gene Therapies“In July 2023, we entered into the License Agreement with AGT where we provided our 4D vector technology to AGT to deliver AGT's genetic payloads for the treatment of rare monogenic diseases.”
CompetitorAbbVie (ABBV)“We consider our most direct competitors in late-stage development with respect to 4D-150 for the treatment of retinal vascular diseases including wet AMD and DME to be late-stage AAV-based anti-VEGF genetic medicine programs including ABBV-RGX-314 from AbbVie Inc. and REGENXBIO Inc. (subretinal delivery in Phase 3 for wet AMD; suprachoroidal delivery initiating Phase 3 for diabetic retinopathy and in Phase 2 for w…”
CompetitorEli Lilly (LLY)“We consider our most direct competitors in late-stage development with respect to 4D-150 for the treatment of retinal vascular diseases including wet AMD and DME to be late-stage AAV-based anti-VEGF genetic medicine programs including ABBV-RGX-314 from AbbVie Inc. and REGENXBIO Inc. (subretinal delivery in Phase 3 for wet AMD; suprachoroidal delivery initiating Phase 3 for diabetic retinopathy and in Phase 2 for w…”
CompetitorJohnson & Johnson (JNJ)“Companies that we are aware are developing therapeutics in the retina and pulmonology disease areas include large companies with significant financial resources, such as AbbVie Inc, Astellas Pharma Inc., Eli Lilly and Company, Johnson & Johnson, Merck & Company Inc., Regeneron Pharmaceuticals Inc., Roche, Sanofi and Vertex Pharmaceuticals Incorporated, and biopharmaceutical companies such as Apellis Pharmaceutical…”

Quoted from the company's 10-K filed Mar 18, 2026.

FDMT company outlook (results filed Aug 13, 2026)

Quoted word-for-word from the SEC 8-K results press release.

FDMT analyst estimates and revisions

PeriodEPS estimate90 days agoChangeRevenue estimateAnalysts
Current quarter (ends Sep 2026)$-1.05$-1.01−$0.04$3.1M11
Next quarter (ends Dec 2026)$-1.06$-1.00−$0.06$3.9M11
Current fiscal year (ends Dec 2026)$-4.15$-3.93−$0.22$13.3M11
Next fiscal year (ends Dec 2027)$-4.09$-3.77−$0.33$20.6M10

FDMT options: expected move

Options price a move of about ±41.0% (±$5.15) by Nov 20, 2026, which includes earnings on Nov 10, 2026. Over the last 8 reports the stock moved ±3.1% on average.

ExpirationDaysATM implied volatilityExpected move
Nov 20, 202622207.0%±41.0%
Dec 18, 202650144.5%±42.6%
Jan 15, 202778108.5%±41.4%
Apr 16, 202716979.9%±43.8%
Jul 16, 202726099.3%±65.3%

30-day implied volatility 76.7% vs 69.2% realized over the last 30 trading days. Put/call ratio (volume) 0. Cboe delayed quotes (15 min). Expected move = at-the-money straddle.

Key Statistics (as of October 29, 2026 at 21:08 UTC)

PriceUSD 12.78
Change▼ 1.16% (down)
Previous CloseUSD 12.93
OpenUSD 13
Day RangeUSD 12.57 – 13.46
52-Week RangeUSD 6.96 – 16.93
Volume848,889 shares
Market Cap$706.02M
ExchangeNMS

Technical Analysis (FDMT)

Nexqual's technical model rates FDMT "NEUTRAL" based on 2 bullish and 3 bearish signals across 127 daily candles, as of October 29, 2026 at 21:08 UTC.

Overall SignalNEUTRAL
RSI (14)50.8 (neutral)
vs SMA50Below (USD 13.8)
MACD-0.42 (negative)

Analyst Ratings (FDMT)

Wall Street analysts rate FDMT "Buy" based on 12 analysts, with a mean price target of USD 28.09 (range USD 18–37), per Nexqual as of October 29, 2026 at 21:08 UTC.

Consensus RatingBuy
Analyst Count12
Mean TargetUSD 28.09
High TargetUSD 37
Low TargetUSD 18
Buy / Hold / Sell11 / 1 / 0

Earnings (FDMT)

Next Earnings Date2026-11-10
EPS EstimateUSD -1.05
Revenue Estimate$3.10M

Recent Earnings History

QuarterActual vs Estimate
2026-06-30USD -1.04 vs est -1.02 ▼ miss
2026-03-31USD -1.01 vs est -1 ▼ miss
2025-12-31USD 0.43 vs est -0.53 ▲ beat
2025-09-30USD -1.01 vs est -0.98 ▼ miss

Source: Nexqual, October 29, 2026 at 21:08 UTC.

Financials & Fundamentals (FDMT)

Total Revenue$92.01M
Revenue Growth (latest quarter, YoY)+25106.70%
Gross Margin-157.70%
Operating Margin-2037.16%
Profit Margin-194.74%
ROE-43.25%
Debt / Equity0.1
Current Ratio8.03
Total Cash$361.33M
Total Debt$39.22M
Free Cash Flow (fiscal year ended Dec 2025, SEC 10-K)-$109.62M (-128.6% of revenue)

Source: Nexqual, October 29, 2026 at 21:08 UTC.

Financial Health Score (FDMT)

Nexqual rates 4D Molecular Therapeutics, Inc.'s overall financial health "Weak" across five dimensions, as of October 29, 2026 at 21:08 UTC.

GrowthMixed — No data
ProfitabilityCritical — Heavily loss-making — early-stage company
Balance SheetStrong — $361M cash and investments vs $20M debt (Jun 2026, SEC), net cash
Cash FlowWeak — FCF negative: -$110M (FY ended Dec 2025, 10-K), burning cash
EfficiencyCritical — ROE -44%, ROA -36.4% (last 4 quarters, SEC)

Ownership (FDMT)

Insider Ownership+2.72%
Institutional Ownership+106.14%
Shares Outstanding55.24M
Float42.55M
Short % of Float+23.93%

Source: Nexqual, October 29, 2026 at 21:08 UTC.

Leadership (FDMT)

4D Molecular Therapeutics, Inc. is led by David H. Kirn, Co-Founder, President, CEO & Director, per Nexqual as of October 29, 2026 at 21:08 UTC.

Co-Founder, President, CEO & DirectorDavid H. Kirn
Executive ChairmanJohn F. Milligan
CFO and Principal Financial & Accounting OfficerKristian Humer
Chief Scientific AdvisorNoriyuki Kasahara

Major Backers & Investors (FDMT)

Notable institutional backers of 4D Molecular Therapeutics, Inc. include Jupiter Topco LLC, RA Capital Management, L.P., Goldman Sachs, according to Nexqual as of October 29, 2026 at 21:08 UTC.

Active Investors

InvestorStake
Jupiter Topco LLC10.4%
RA Capital Management, L.P.9.14%
Goldman Sachs7.71%
Novo Holdings A/S5.88%
BVF Inc.5.21%
T. Rowe Price4.55%
Adage Capital Partners GP L.L.C.4.07%
Trails Edge Capital Partners, LP4.03%

Index Funds (Passive)

FundStake
BlackRock8.23%
State Street5.27%

Source: Nexqual, October 29, 2026 at 21:08 UTC.

From 4D Molecular Therapeutics, Inc.'s Latest SEC 10-K Filing (filed 2026-03-18)

Key Strengths & Strategy (as disclosed to the SEC)

Partnerships

Legal & Regulatory Risks (Item 1A, quoted)

Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.

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Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 29, 2026 at 21:08 UTC. This page is informational and not investment advice.

For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt