4D Molecular Therapeutics, Inc. (FDMT) Stock Price & Analysis
4D Molecular Therapeutics, Inc. (FDMT) closed at USD 12.78 on Thursday, October 29, 2026, down 1.16% on the day. The US market is currently closed (after-hours); this is not a live price.
The prior close was USD 12.93; the Oct 29, 2026 session ranged USD 12.57–13.46 on volume of 848,889 shares. Market capitalization is $706.02M, with a 52-week range of USD 6.96–16.93 (NMS). Source: Nexqual, retrieved October 29, 2026 at 21:08 UTC.
Also available as compact Markdown for AI agents: nexqual.com/FDMT.md
Key facts (FDMT)
- Last four reported quarters (through Jun 30, 2026): revenue $92.0M, net income -$179M (-194.7% margin) (SEC filings).
- Insider open-market sales, last ~7 months: 14 Form 4 filings, $5.3M; 0 not under a Rule 10b5-1 plan ($0K); 6 by opportunistic insiders (0 outside 10b5-1 plans), 0 by routine insiders (three-year test, Cohen, Malloy & Pomorski 2012).
- Analysts: Buy (mean 1.92 on a 1–5 scale) (12 analysts), mean target USD 28.09 (range 18–37).
- Total return with dividends: 1Y +12.9% vs S&P 500 +14.4%; 5Y -46.8% vs S&P 500 +79.1%.
- Next earnings: 2026-11-10, EPS estimate USD -1.05, revenue estimate $3.1M.
Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (FDMT)
| USD | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 | TTM |
|---|---|---|---|---|---|---|
| Revenue | $18.0M | $3.1M | $20.7M | $37K | $85.2M | $92.0M |
| Operating income | -$71.3M | -$110M | -$113M | -$188M | -$160M | -$197M |
| Net income | -$71.3M | -$107M | -$101M | -$161M | -$140M | -$179M |
| EPS (diluted) | -$2.57 | -$3.32 | -$2.58 | -$2.98 | -$2.42 | — |
| Free cash flow | -$78.2M | -$98.2M | -$78.6M | -$138M | -$110M | — |
| Operating margin | -395.5% | -3516.5% | -544.6% | -507678.4% | -187.2% | -214.2% |
| Net margin | -395.4% | -3435.4% | -486.6% | -434778.4% | -164.4% | -194.7% |
| Revenue growth | +32.5% | -82.7% | +562.3% | -99.8% | +230194.6% | — |
| Cash + short-term investments | $248M | $214M | $288M | $425M | $514M | — |
| Total debt | — | — | — | — | $0K | — |
Fiscal years end Dec. EPS is split-adjusted.
Valuation (price ÷ last four quarters, through Jun 30, 2026) (FDMT)
P/S 7.7x · EV/Sales 4.0x · P/B 1.7x · Earnings yield -25.38% · Net cash $342M · EV $364M
Insider sales (SEC Form 4, open-market, last ~7 months) (FDMT)
14 of 14 under a Rule 10b5-1 trading plan (scheduled in advance). Unplanned sales were timed by the insider.
| Trade date | Insider | Role | Shares | Value | % of holdings sold | 10b5-1 plan | Insider type |
|---|---|---|---|---|---|---|---|
| 2026-10-16 | Bizily Scott | Chief Legal Officer | 1,635 | $21K | 15.9% | Yes (adopted January 13, 2026) | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-10-05 | Kirn David | See Remarks | 58,333 | $754K | 7.6% | Yes (adopted January 9, 2026) | Too little history (no open-market trades in 2025) |
| 2026-09-16 | Bizily Scott | Chief Legal Officer | 1,635 | $22K | 15.9% | Yes (adopted January 13, 2026) | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-09-14 | Kirn David | See Remarks | 58,333 | $811K | 7.1% | Yes (adopted January 9, 2026) | Too little history (no open-market trades in 2025) |
| 2026-09-01 | Bizily Scott | Chief Legal Officer | 584 | $8K | 6.3% | Yes (adopted January 13, 2026) | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-08-19 | Kirn David | See Remarks | 69,076 | $1.1M | 7.7% | Yes (adopted January 9, 2026) | Too little history (no open-market trades in 2025) |
| 2026-08-13…2026-08-17 | Bizily Scott | Chief Legal Officer | 3,270 | $40K | 27.5% | Yes (adopted January 13, 2026) | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-08-04 | Kirn David | See Remarks | 26,842 | $275K | 3.1% | Yes (adopted January 9, 2026) | Too little history (no open-market trades in 2025) |
| 2026-08-03 | Kirn David | See Remarks | 12,415 | $125K | 1.4% | Yes (adopted January 9, 2026) | Too little history (no open-market trades in 2025) |
| 2026-07-09…2026-07-10 | Kirn David | See Remarks | 58,333 | $737K | 6.2% | Yes (adopted January 9, 2026) | Too little history (no open-market trades in 2025) |
| 2026-06-30 | Bizily Scott | Chief Legal Officer | 6,566 | $92K | 43.2% | Yes (adopted January 13, 2026) | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-06-23 | Bizily Scott | Chief Legal Officer | 9,810 | $118K | 53.2% | Yes | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-06-22 | Kirn David | See Remarks | 114,746 | $1.2M | 10.9% | Yes (adopted January 9, 2026) | Too little history (no open-market trades in 2025) |
| 2026-06-01 | Kirn David | See Remarks | 1,922 | $19K | 0.2% | Yes (adopted January 9, 2026) | Too little history (no open-market trades in 2025) |
% of holdings sold = shares sold ÷ (shares sold + all holdings the insider reported on that Form 4, direct and through trusts).
Insider type follows Cohen, Malloy & Pomorski (Journal of Finance, 2012). An insider who traded the stock in the same calendar month in each of the past three years is a routine trader; one who traded in each of those years without such a pattern is an opportunistic trader. In their study, trades by opportunistic insiders predicted future returns and trades by routine insiders did not. Counts open-market purchases and sales only (SEC Form 4 codes P and S) by that insider in that company. Not investment advice.
Analysts (FDMT)
Consensus Buy (mean 1.92 on a 1–5 scale), 12 analysts; mean target USD 28.09 (low 18, high 37).
Rating changes, last 120 days:
| Date | Firm | Action | Rating | Price target |
|---|---|---|---|---|
| 2026-10-22 | HC Wainwright & Co. | Reiterated | Buy | $36 |
| 2026-10-06 | Chardan Capital | Target lowered | Buy | $26 → $25 |
| 2026-09-29 | B of A Securities | Target raised | Buy | $29 → $33 |
| 2026-09-14 | Cantor Fitzgerald | Upgrade | Neutral → Overweight | $20 |
| 2026-07-31 | B. Riley Securities | Initiated | Buy | $37 |
| 2026-07-20 | HC Wainwright & Co. | Reiterated | Buy | $36 |
Total return (dividends reinvested) (FDMT)
| 1Y (from 2025-10-30) | 5Y (from 2021-10-25) | |
|---|---|---|
| Total return | +12.9% | -46.8% |
| S&P 500 (SPY) | +14.4% | +79.1% |
| Per year | +12.9% | -11.8% |
| Volatility (annualized) | 76.3% | 87.0% |
| Max drawdown | -38.3% (Nov 2025→Jan 2026) | -92.2% (Mar 2024→Apr 2025) |
FDMT earnings history and stock reaction
| Results filed | Quarter | EPS | Consensus | Surprise | Stock reaction |
|---|---|---|---|---|---|
| Aug 13, 2026 | Quarter ended Jun 30, 2026 | −$1.04 | −$1.02 | Miss −2.0% | +2.7% |
| May 7, 2026 | Quarter ended Mar 31, 2026 | −$1.01 | −$1.00 | Miss −1.0% | -2.7% |
| Mar 18, 2026 | Quarter ended Dec 31, 2025 | $0.43 | −$0.53 | Beat +$0.96 | +4.3% |
| Jan 7, 2026 | Quarter ended Sep 30, 2025 | −$1.01 | −$0.98 | Miss −3.1% | +1.5% |
| Nov 10, 2025 | Quarter ended Sep 30, 2025 | −$1.01 | −$0.98 | Miss −3.1% | +2.9% |
| Nov 6, 2025 | Quarter ended Sep 30, 2025 | −$1.01 | −$0.98 | Miss −3.1% | -0.1% |
| Aug 11, 2025 | — | — | — | — | +9.2% |
| May 8, 2025 | — | — | — | — | -1.1% |
EPS as reported against the analyst consensus before the release; surprise uses the cent-rounded figures shown (in dollars when EPS and consensus have opposite signs). Stock reaction = close before the results to close after (the first close following a release after the bell or before the open).
FDMT recent SEC filings (last 120 days)
| Filed | Form | What it says |
|---|---|---|
| Sep 28, 2026 | 8-K | Other material event “On September 28, 2026, 4D Molecular Therapeutics, Inc. (the "Company") reported that the first patients have been enrolled across multiple sites in the 4SIGHT Phase 3 clinical trial evaluating 4D-150 for the treatment of diabetic macular edema ("DME"). The Company also reported 2-year data from the SPECTRA clinical trial. 4SIGHT: Phase 3 Trial Design and Regulatory Pathway 4SIGHT is a global Phase 3 multicenter, randomized, double-masked, aflibercept 2 mg ("Q8W") comparator-controlled trial of intravitreal 4D-150…” |
| Aug 13, 2026 | 10-Q | Quarterly report · period ended Jun 30, 2026 |
| Aug 13, 2026 | 8-K | Quarterly results |
| Jul 20, 2026 | 8-K | Other material event “On July 18, 2026, 4D Molecular Therapeutics, Inc. (the "Company") reported positive 2-year data from the PRISM Phase 2b clinical trial evaluating 4D-150 in a broad wet age-related macular degeneration ("wet AMD") population. 2-Year Data from PRISM Phase 2b Clinical Trial (Data Cutoff May 18, 2026): Trial and Patient Cohort Overview The Phase 2b trial enrolled 45 patients at two dose levels of a single intravitreal dose of 4D-150 (3E10 and 1E10 vg/eye); 3E10 vg/eye was chosen as the dose for the 4FRONT Phase 3…” |
Source: SEC EDGAR. Quotes are the opening words of each item as filed; each form links to the filing. Insider Form 4 filings are listed in the insider sections.
FDMT suppliers, customers and competitors (named in its 10-K)
| Relationship | Company | Sentence in the filing |
|---|---|---|
| Partner | Otsuka Pharmaceutical | “the expected potential benefits of strategic collaboration agreements, including our relationships with Otsuka Pharmaceutical Co., Ltd. and Cystic Fibrosis Foundation, and our ability to attract collaborators with development, regulatory and commercialization expertise;” |
| Partner | AMD (AMD) | “On October 31, 2025, we entered into a Collaboration and License Agreement ("Otsuka Collaboration and License Agreement") with Otsuka Pharmaceutical Co., Ltd. ("Otsuka"), pursuant to which we granted Otsuka exclusive rights to develop and commercialize 4D-150 for retinal vascular diseases, including wet AMD and DME, in Japan, China, Australia, and other Asia-Pacific ("APAC") markets.” |
| Partner | Astellas Gene Therapies | “In July 2023, we entered into the License Agreement with AGT where we provided our 4D vector technology to AGT to deliver AGT's genetic payloads for the treatment of rare monogenic diseases.” |
| Competitor | AbbVie (ABBV) | “We consider our most direct competitors in late-stage development with respect to 4D-150 for the treatment of retinal vascular diseases including wet AMD and DME to be late-stage AAV-based anti-VEGF genetic medicine programs including ABBV-RGX-314 from AbbVie Inc. and REGENXBIO Inc. (subretinal delivery in Phase 3 for wet AMD; suprachoroidal delivery initiating Phase 3 for diabetic retinopathy and in Phase 2 for w…” |
| Competitor | Eli Lilly (LLY) | “We consider our most direct competitors in late-stage development with respect to 4D-150 for the treatment of retinal vascular diseases including wet AMD and DME to be late-stage AAV-based anti-VEGF genetic medicine programs including ABBV-RGX-314 from AbbVie Inc. and REGENXBIO Inc. (subretinal delivery in Phase 3 for wet AMD; suprachoroidal delivery initiating Phase 3 for diabetic retinopathy and in Phase 2 for w…” |
| Competitor | Johnson & Johnson (JNJ) | “Companies that we are aware are developing therapeutics in the retina and pulmonology disease areas include large companies with significant financial resources, such as AbbVie Inc, Astellas Pharma Inc., Eli Lilly and Company, Johnson & Johnson, Merck & Company Inc., Regeneron Pharmaceuticals Inc., Roche, Sanofi and Vertex Pharmaceuticals Incorporated, and biopharmaceutical companies such as Apellis Pharmaceutical…” |
Quoted from the company's 10-K filed Mar 18, 2026.
FDMT company outlook (results filed Aug 13, 2026)
- “Based on our current operating plan, we estimate that our existing cash, cash equivalents and marketable securities, and expected payments under our collaboration agreement with Otsuka, will be sufficient to fund our operating expenses and capital expenditure requirements at least into the second half of 2028.”
Quoted word-for-word from the SEC 8-K results press release.
FDMT analyst estimates and revisions
| Period | EPS estimate | 90 days ago | Change | Revenue estimate | Analysts |
|---|---|---|---|---|---|
| Current quarter (ends Sep 2026) | $-1.05 | $-1.01 | −$0.04 | $3.1M | 11 |
| Next quarter (ends Dec 2026) | $-1.06 | $-1.00 | −$0.06 | $3.9M | 11 |
| Current fiscal year (ends Dec 2026) | $-4.15 | $-3.93 | −$0.22 | $13.3M | 11 |
| Next fiscal year (ends Dec 2027) | $-4.09 | $-3.77 | −$0.33 | $20.6M | 10 |
FDMT options: expected move
Options price a move of about ±41.0% (±$5.15) by Nov 20, 2026, which includes earnings on Nov 10, 2026. Over the last 8 reports the stock moved ±3.1% on average.
| Expiration | Days | ATM implied volatility | Expected move |
|---|---|---|---|
| Nov 20, 2026 | 22 | 207.0% | ±41.0% |
| Dec 18, 2026 | 50 | 144.5% | ±42.6% |
| Jan 15, 2027 | 78 | 108.5% | ±41.4% |
| Apr 16, 2027 | 169 | 79.9% | ±43.8% |
| Jul 16, 2027 | 260 | 99.3% | ±65.3% |
30-day implied volatility 76.7% vs 69.2% realized over the last 30 trading days. Put/call ratio (volume) 0. Cboe delayed quotes (15 min). Expected move = at-the-money straddle.
Key Statistics (as of October 29, 2026 at 21:08 UTC)
| Price | USD 12.78 |
|---|---|
| Change | ▼ 1.16% (down) |
| Previous Close | USD 12.93 |
| Open | USD 13 |
| Day Range | USD 12.57 – 13.46 |
| 52-Week Range | USD 6.96 – 16.93 |
| Volume | 848,889 shares |
| Market Cap | $706.02M |
| Exchange | NMS |
Technical Analysis (FDMT)
Nexqual's technical model rates FDMT "NEUTRAL" based on 2 bullish and 3 bearish signals across 127 daily candles, as of October 29, 2026 at 21:08 UTC.
| Overall Signal | NEUTRAL |
|---|---|
| RSI (14) | 50.8 (neutral) |
| vs SMA50 | Below (USD 13.8) |
| MACD | -0.42 (negative) |
Analyst Ratings (FDMT)
Wall Street analysts rate FDMT "Buy" based on 12 analysts, with a mean price target of USD 28.09 (range USD 18–37), per Nexqual as of October 29, 2026 at 21:08 UTC.
| Consensus Rating | Buy |
|---|---|
| Analyst Count | 12 |
| Mean Target | USD 28.09 |
| High Target | USD 37 |
| Low Target | USD 18 |
| Buy / Hold / Sell | 11 / 1 / 0 |
Earnings (FDMT)
| Next Earnings Date | 2026-11-10 |
|---|---|
| EPS Estimate | USD -1.05 |
| Revenue Estimate | $3.10M |
Recent Earnings History
| Quarter | Actual vs Estimate |
|---|---|
| 2026-06-30 | USD -1.04 vs est -1.02 ▼ miss |
| 2026-03-31 | USD -1.01 vs est -1 ▼ miss |
| 2025-12-31 | USD 0.43 vs est -0.53 ▲ beat |
| 2025-09-30 | USD -1.01 vs est -0.98 ▼ miss |
Source: Nexqual, October 29, 2026 at 21:08 UTC.
Financials & Fundamentals (FDMT)
| Total Revenue | $92.01M |
|---|---|
| Revenue Growth (latest quarter, YoY) | +25106.70% |
| Gross Margin | -157.70% |
| Operating Margin | -2037.16% |
| Profit Margin | -194.74% |
| ROE | -43.25% |
| Debt / Equity | 0.1 |
| Current Ratio | 8.03 |
| Total Cash | $361.33M |
| Total Debt | $39.22M |
| Free Cash Flow (fiscal year ended Dec 2025, SEC 10-K) | -$109.62M (-128.6% of revenue) |
Source: Nexqual, October 29, 2026 at 21:08 UTC.
Financial Health Score (FDMT)
Nexqual rates 4D Molecular Therapeutics, Inc.'s overall financial health "Weak" across five dimensions, as of October 29, 2026 at 21:08 UTC.
| Growth | Mixed — No data |
|---|---|
| Profitability | Critical — Heavily loss-making — early-stage company |
| Balance Sheet | Strong — $361M cash and investments vs $20M debt (Jun 2026, SEC), net cash |
| Cash Flow | Weak — FCF negative: -$110M (FY ended Dec 2025, 10-K), burning cash |
| Efficiency | Critical — ROE -44%, ROA -36.4% (last 4 quarters, SEC) |
Ownership (FDMT)
| Insider Ownership | +2.72% |
|---|---|
| Institutional Ownership | +106.14% |
| Shares Outstanding | 55.24M |
| Float | 42.55M |
| Short % of Float | +23.93% |
Source: Nexqual, October 29, 2026 at 21:08 UTC.
Leadership (FDMT)
4D Molecular Therapeutics, Inc. is led by David H. Kirn, Co-Founder, President, CEO & Director, per Nexqual as of October 29, 2026 at 21:08 UTC.
| Co-Founder, President, CEO & Director | David H. Kirn |
|---|---|
| Executive Chairman | John F. Milligan |
| CFO and Principal Financial & Accounting Officer | Kristian Humer |
| Chief Scientific Advisor | Noriyuki Kasahara |
Major Backers & Investors (FDMT)
Notable institutional backers of 4D Molecular Therapeutics, Inc. include Jupiter Topco LLC, RA Capital Management, L.P., Goldman Sachs, according to Nexqual as of October 29, 2026 at 21:08 UTC.
Active Investors
| Investor | Stake |
|---|---|
| Jupiter Topco LLC | 10.4% |
| RA Capital Management, L.P. | 9.14% |
| Goldman Sachs | 7.71% |
| Novo Holdings A/S | 5.88% |
| BVF Inc. | 5.21% |
| T. Rowe Price | 4.55% |
| Adage Capital Partners GP L.L.C. | 4.07% |
| Trails Edge Capital Partners, LP | 4.03% |
Index Funds (Passive)
| Fund | Stake |
|---|---|
| BlackRock | 8.23% |
| State Street | 5.27% |
Source: Nexqual, October 29, 2026 at 21:08 UTC.
From 4D Molecular Therapeutics, Inc.'s Latest SEC 10-K Filing (filed 2026-03-18)
Key Strengths & Strategy (as disclosed to the SEC)
- On October 31, 2025, we entered into a Collaboration and License Agreement ("Otsuka Collaboration and License Agreement") with Otsuka Pharmaceutical Co., Ltd. ("Otsuka"), pursuant to which we granted Otsuka exclusive rights to develop and commercialize 4D-150 for retinal vascular diseases, including wet AMD and DME, in Japan, China, Australia, and other Asia-Pacific ("APAC") markets.
- Our proprietary Therapeutic Vector Evolution Platform is based on the principles of directed evolution.
- Bolus anti-VEGF treatment of retinal vascular diseases represents global branded therapeutic markets of over $16 billion, with wet AMD and DME comprising approximately $14 billion.
- We believe our proprietary vectors will allow us to overcome known limitations of conventional AAV vectors, and to potentially address a broad range of diseases that affect both large and rare patient populations that cannot be addressed with conventional vectors.
Partnerships
- We are currently enrolling the Phase 2 portion of the AEROW Phase 1/2 clinical trial in people with CF with funding from and in collaboration with the CF Foundation.
Legal & Regulatory Risks (Item 1A, quoted)
- Changes in applicable regulatory guidelines may lengthen the regulatory review process, require us to perform additional studies or trials, increase our development costs, lead to changes in regulatory positions and interpretations, delay or prevent approval and commercialization of our product candidates or lead to significant post-approval limitations or restrictions.
- Adverse public perception or regulatory scrutiny of genetic medicine technology may negatively impact the developmental progress or commercial success of product candidates that we develop alone or with collaborators.
- Our product candidates may cause undesirable side effects or have other properties that could halt their clinical development, prevent their regulatory approval, limit their commercial potential or result in significant negative consequences.
- Adverse events or other undesirable side effects caused by our product candidates could cause us or regulatory authorities to interrupt, delay or halt clinical trials and could result in a more restrictive label or the delay or denial of regulatory approval by the FDA or other comparable foreign regulatory authorities.
Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.
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| IONS | Ionis Pharmaceuticals, Inc. | USD 44.39 | ▼ 1.14% |
| AXSM | Axsome Therapeutics, Inc. | USD 143.45 | ▼ 0.04% |
| ABVX | Abivax SA | USD 89.06 | ▼ 0.87% |
Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 29, 2026 at 21:08 UTC. This page is informational and not investment advice.
For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt