Kymera Therapeutics, Inc. (KYMR) Stock Price & Analysis

Kymera Therapeutics, Inc. (KYMR) closed at USD 110.85 on Thursday, October 22, 2026, down 1.58% on the day. The US market is currently closed (pre-market); this is not a live price.

The prior close was USD 112.63; the Oct 22, 2026 session ranged USD 110.16–113.73 on volume of 850,259 shares. Market capitalization is $9.12B, with a 52-week range of USD 55.26–130.05 (NGM). Source: Nexqual, retrieved October 23, 2026 at 10:04 UTC.

Also available as compact Markdown for AI agents: nexqual.com/KYMR.md

Key facts (KYMR)

Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (KYMR)

USDFY2021FY2022FY2023FY2024FY2025TTM
Revenue$72.8M$46.8M$78.6M$47.1M$39.2M$105M
Gross profit—$0K$0K$0K$0K—
Operating income-$101M-$161M-$166M-$262M-$349M-$350M
Net income-$100M-$155M-$147M-$224M-$311M-$300M
EPS (diluted)-$2.09-$2.87-$2.52-$2.98-$3.69—
Free cash flow-$131M-$156M-$137M-$207M-$234M-$238M
Gross margin—0.0%0.0%0.0%0.0%—
Operating margin-138.0%-344.4%-210.6%-555.8%-891.1%-333.5%
Net margin-137.6%-330.6%-187.0%-475.6%-794.0%-285.3%
Revenue growth+114.0%-35.7%+67.8%-40.1%-16.7%—
Cash + short-term investments$442M$407M$375M$489M$848M—

Fiscal years end Dec. EPS is split-adjusted.

Valuation (price ÷ last four quarters, through Jun 30, 2026) (KYMR)

P/S 86.8x · P/B 6.0x · FCF yield -2.61% · Earnings yield -3.29%

Insider sales (SEC Form 4, open-market, last ~7 months) (KYMR)

22 of 24 under a Rule 10b5-1 trading plan (scheduled in advance). Unplanned sales were timed by the insider.

Trade dateInsiderRoleSharesValue% of holdings sold10b5-1 planInsider type
2026-10-01Mainolfi NelloChief Executive Officer30,000$3.4M4.3%YesToo little history (no open-market trades in 2023 or 2024)
2026-09-04Adams BrianChief Legal Officer6,371$744K11.3%NoToo little history (no open-market trades in 2023–2025)
2026-07-07Mainolfi NelloChief Executive Officer50,000$6.0M7%YesToo little history (no open-market trades in 2023 or 2024)
2026-07-01Goodman NoahChief Business Officer3,389$387K6.7%YesToo little history (no open-market trades in 2023–2025)
2026-07-01Mainolfi NelloChief Executive Officer80,000$9.2M10.7%YesToo little history (no open-market trades in 2023 or 2024)
2026-06-30Jacobs Bruce N.Chief Financial Officer77,109$8.9M23.9%YesRoutine (sold in Mar each year 2023–2025; this trade is outside those months)
2026-06-29Booth BruceDirector31,283$3.4M6.3%YesOpportunistic (traded every year 2023–2025, no repeating month)
2026-06-26…2026-06-29Booth BruceDirector513,245$56.5M52.4%YesOpportunistic (traded every year 2023–2025, no repeating month)
2026-06-26Bvf Partners L P/ilDirector1,630,658$174M83.6%NoToo little history (no open-market trades in 2024)
2026-06-25Booth BruceDirector285,684$34.8M35%YesOpportunistic (traded every year 2023–2025, no repeating month)
2026-06-23…2026-06-25Booth BruceDirector398,765$44.0M41.4%YesOpportunistic (traded every year 2023–2025, no repeating month)
2026-06-25Goodman NoahChief Business Officer5,000$570K9.1%YesToo little history (no open-market trades in 2023–2025)
2026-06-22Booth BruceDirector31,798$3.3M4.9%YesOpportunistic (traded every year 2023–2025, no repeating month)
2026-06-17…2026-06-22Booth BruceDirector478,198$45.3M43.6%Yes (adopted December 16, 2025)Opportunistic (traded every year 2023–2025, no repeating month)
2026-06-22Goodman NoahChief Business Officer2,500$248K4.7%YesToo little history (no open-market trades in 2023–2025)
2026-05-26…2026-05-27Chadwick Jeremy GChief Operating Officer17,184$1.4M28.1%YesToo little history (no open-market trades in 2023)
2026-05-11Ridloff ElenaDirector3,000$261K100%YesToo little history (no open-market trades in 2023 or 2024)
2026-04-29Mainolfi NelloChief Executive Officer30,000$2.4M4.3%YesToo little history (no open-market trades in 2023 or 2024)
2026-04-22Booth BruceDirector6,000$540K0.9%Yes (adopted December 16, 2025)Opportunistic (traded every year 2023–2025, no repeating month)
2026-04-22Chadwick Jeremy GChief Operating Officer300$27K0.5%YesToo little history (no open-market trades in 2023)

% of holdings sold = shares sold ÷ (shares sold + all holdings the insider reported on that Form 4, direct and through trusts).

Insider type follows Cohen, Malloy & Pomorski (Journal of Finance, 2012). An insider who traded the stock in the same calendar month in each of the past three years is a routine trader; one who traded in each of those years without such a pattern is an opportunistic trader. In their study, trades by opportunistic insiders predicted future returns and trades by routine insiders did not. Counts open-market purchases and sales only (SEC Form 4 codes P and S) by that insider in that company. Not investment advice.

Analysts (KYMR)

Consensus Buy (mean 1.88 on a 1–5 scale), 24 analysts; mean target USD 139.35 (low 111, high 180).

Rating changes, last 120 days:

DateFirmActionRatingPrice target
2026-10-09Raymond JamesInitiatedOutperform$140
2026-10-05CitigroupTarget raisedBuy$135 → $150
2026-09-22StifelTarget raisedBuy$132 → $152
2026-09-14B of A SecuritiesTarget raisedBuy$123 → $144
2026-09-10Wolfe ResearchUpgradePeer Perform → Outperform
2026-08-31GuggenheimTarget raisedBuy$135 → $170
2026-08-27Wells FargoTarget raisedOverweight$116 → $151
2026-08-06BarclaysTarget raisedOverweight$133 → $139
2026-07-30Deutsche BankInitiatedHold$120
2026-07-28GuggenheimTarget raisedBuy$125 → $135
2026-07-16MizuhoTarget raisedOutperform$120 → $140
2026-07-13RBC CapitalDowngradeOutperform → Sector Perform$106 → $115

Total return (dividends reinvested) (KYMR)

1Y (from 2025-10-23)5Y (from 2021-10-18)
Total return+91.9%+99.1%
S&P 500 (SPY)+14.9%+80.3%
Per year+92.3%+14.7%
Volatility (annualized)57.8%72.8%
Max drawdown-27.7% (Dec 2025→Jan 2026)-83.1% (Nov 2021→Oct 2023)

KYMR suppliers, customers and competitors (named in its 10-K)

RelationshipCompanySentence in the filing
CustomerJefferies“Sales to, or through, Jefferies by us could result in substantial dilution to the interests of other holders of our common stock.”
PartnerSanofi (SNY)“We are collaborating with Sanofi S.A. ("Sanofi") on the development of our IRAK4 degrader, KT-485/SAR447971, which Sanofi plans to advance into clinical testing in 2026.”
PartnerGILEAD SCIENCES, INC. (GILD)“In June 2025, we announced a strategic collaboration with Gilead Sciences, Inc. ("Gilead") to develop novel oral molecular glue degraders for CDK2.”
PartnerVertex Pharmaceuticals“Our only revenues have been derived from research collaboration arrangements with Vertex Pharmaceuticals Incorporated, or Vertex,, Sanofi and Gilead.”
PartnerJohnson & Johnson (JNJ)“In particular, several pharmaceutical companies have announced partnerships around programs targeting STAT6, and/or have their own internal STAT6 programs, including Gilead Sciences, Inc, Johnson & Johnson, Pfizer and Sanofi.”
PartnerCowen and Company“To date, we have received gross proceeds of $2.75 billion from sales of our convertible preferred stock, the sale of common stock including our August 2020 initial public offering, or IPO, and concurrent private placement, our subsequent follow-on offerings and private placement offering, our prior sales agreement with Cowen and through our corporate collaborations.”
PartnerPfizer (PFE)“In particular, several pharmaceutical companies have announced partnerships around programs targeting STAT6, and/or have their own internal STAT6 programs, including Gilead Sciences, Inc, Johnson & Johnson, Pfizer and Sanofi.”

Quoted from the company's 10-K filed Feb 26, 2026.

Companies that name KYMR in their SEC reports

Relationship to KYMRCompanyFilingSentence
partnerGILEAD SCIENCES, INC. (GILD)10-K Feb 24, 2026“•Entered into an exclusive option and license agreement with Kymera Therapeutics, Inc. to develop novel oral molecular glue CDK2 degraders with broad oncology treatment potential.”

KYMR company outlook (results filed Aug 5, 2026)

Quoted word-for-word from the SEC 8-K results press release.

KYMR analyst estimates and revisions

PeriodEPS estimate90 days agoChangeRevenue estimateAnalysts
Current quarter (ends Sep 2026)$-1.27$-1.03+23.3%$2.9M21
Next quarter (ends Dec 2026)$-1.25$-1.03+21.9%$3.3M21
Current fiscal year (ends Dec 2026)$-3.85$-3.51+9.6%$104.8M21
Next fiscal year (ends Dec 2027)$-5.10$-4.35+17.2%$40.7M21

KYMR options: expected move

Options price a move of about ±24.6% (±$27.25) by Nov 20, 2026, which includes earnings on Oct 29, 2026. Over the last 8 reports the stock moved ±3.1% on average.

ExpirationDaysATM implied volatilityExpected move
Nov 20, 202628110.1%±24.6%
Dec 18, 202656168.0%±51.7%
Jan 15, 202784147.0%±55.0%
Feb 19, 2027119128.1%±56.8%
Mar 19, 2027147118.5%±58.2%
May 21, 2027210104.9%±61.2%

30-day implied volatility 109.6% vs 40.3% realized over the last 30 trading days. Put/call ratio (volume) 1.6. Cboe delayed quotes (15 min). Expected move = at-the-money straddle.

Key Statistics (as of October 23, 2026 at 10:04 UTC)

PriceUSD 110.85
Change▼ 1.58% (down)
Previous CloseUSD 112.63
OpenUSD 111.43
Day RangeUSD 110.16 – 113.73
52-Week RangeUSD 55.26 – 130.05
Volume850,259 shares
Market Cap$9.12B
ExchangeNGM

Technical Analysis (KYMR)

Nexqual's technical model rates KYMR "NEUTRAL" based on 2 bullish and 3 bearish signals across 127 daily candles, as of October 23, 2026 at 10:04 UTC.

Overall SignalNEUTRAL
RSI (14)49.08 (neutral)
vs SMA50Below (USD 115.09)
MACD-1.06 (negative)

Analyst Ratings (KYMR)

Wall Street analysts rate KYMR "Buy" based on 24 analysts, with a mean price target of USD 139.35 (range USD 111–180), per Nexqual as of October 23, 2026 at 10:04 UTC.

Consensus RatingBuy
Analyst Count24
Mean TargetUSD 139.35
High TargetUSD 180
Low TargetUSD 111
Buy / Hold / Sell22 / 2 / 0

Earnings (KYMR)

Next Earnings Date2026-10-29
EPS EstimateUSD -1.27
Revenue Estimate$2.95M

Recent Earnings History

QuarterActual vs Estimate
2026-06-30USD -0.62 vs est -0.74 ▲ beat
2026-03-31USD -0.71 vs est -0.86 ▲ beat
2025-12-31USD -0.98 vs est -0.77 ▼ miss
2025-09-30USD -0.94 vs est -0.78 ▼ miss

Source: Nexqual, October 23, 2026 at 10:04 UTC.

Financials & Fundamentals (KYMR)

Total Revenue$105.00M
Revenue Growth (latest quarter, YoY)+466.40%
Gross Margin-257.69%
Operating Margin-116.32%
Profit Margin-285.33%
ROE-24.15%
Debt / Equity0.05
Current Ratio10.34
Total Cash$690.99M
Total Debt$78.56M
Free Cash Flow (last four quarters to Jun 2026, SEC 10-Q / 10-K)-$237.96M (-226.6% of revenue)

Source: Nexqual, October 23, 2026 at 10:04 UTC.

Financial Health Score (KYMR)

Nexqual rates Kymera Therapeutics, Inc.'s overall financial health "Weak" across five dimensions, as of October 23, 2026 at 10:04 UTC.

GrowthCritical — Revenue -17% YoY (annual), sharp decline
ProfitabilityWeak — Small revenue base — building scale
Balance SheetStrong — $691M cash vs $79M debt, net cash position
Cash FlowWeak — FCF negative: -$238M (last 4 quarters to Jun 2026, SEC), burning cash
EfficiencyCritical — ROE -24%, ROA -15.6%

Ownership (KYMR)

Insider Ownership+2.12%
Institutional Ownership+119.39%
Shares Outstanding82.26M
Float66.04M
Short % of Float+15.33%

Source: Nexqual, October 23, 2026 at 10:04 UTC.

Leadership (KYMR)

Kymera Therapeutics, Inc. is led by Nello Mainolfi, Co-Founder, President, CEO & Director, per Nexqual as of October 23, 2026 at 10:04 UTC.

Co-Founder, President, CEO & DirectorNello Mainolfi
Chief Financial OfficerBruce N. Jacobs
Vice President of Investor RelationsJustine E. Koenigsberg

Major Backers & Investors (KYMR)

Notable institutional backers of Kymera Therapeutics, Inc. include FMR, LLC, Baker Bros. Advisors, LP, Avoro Capital Advisors LLC, according to Nexqual as of October 23, 2026 at 10:04 UTC.

Active Investors

InvestorStake
FMR, LLC14.85%
Baker Bros. Advisors, LP10.41%
Avoro Capital Advisors LLC8.99%
Price (T.Rowe) Associates Inc8.55%
T. Rowe Price7.53%
BVF Inc.4.66%
Wellington Management4.42%
Siren, L.L.C.3.53%

Index Funds (Passive)

FundStake
BlackRock6.66%
Vanguard Group3.6%

Source: Nexqual, October 23, 2026 at 10:04 UTC.

From Kymera Therapeutics, Inc.'s Latest SEC 10-K Filing (filed 2026-02-26)

Key Strengths & Strategy (as disclosed to the SEC)

Partnerships

Legal & Regulatory Risks (Item 1A, quoted)

Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.

Peers & Related Stocks

SymbolNamePriceChange
IBRXImmunityBio, Inc.USD 8.31▼ 3.82%
CAICaris Life Sciences, Inc.USD 31.71▼ 1.98%
KRYSKrystal Biotech, Inc.USD 320.13▼ 0.63%
PTGXProtagonist Therapeutics, Inc.USD 139.53▲ 1.05%
CYTKCytokinetics, IncorporatedUSD 62.33▼ 0.84%
SYRESpyre Therapeutics, Inc.USD 92.33▼ 0.67%

Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 23, 2026 at 10:04 UTC. This page is informational and not investment advice.

For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt