Kymera Therapeutics, Inc. (KYMR) Stock Price & Analysis
Kymera Therapeutics, Inc. (KYMR) closed at USD 110.85 on Thursday, October 22, 2026, down 1.58% on the day. The US market is currently closed (pre-market); this is not a live price.
The prior close was USD 112.63; the Oct 22, 2026 session ranged USD 110.16–113.73 on volume of 850,259 shares. Market capitalization is $9.12B, with a 52-week range of USD 55.26–130.05 (NGM). Source: Nexqual, retrieved October 23, 2026 at 10:04 UTC.
Also available as compact Markdown for AI agents: nexqual.com/KYMR.md
Key facts (KYMR)
- Last four reported quarters (through Jun 30, 2026): revenue $105M, net income -$300M (-285.3% margin), free cash flow -$238M (SEC filings).
- Insider open-market sales, last ~7 months: 24 Form 4 filings, $397M; 2 not under a Rule 10b5-1 plan ($174M); 8 by opportunistic insiders (0 outside 10b5-1 plans), 1 by routine insiders (three-year test, Cohen, Malloy & Pomorski 2012).
- Analysts: Buy (mean 1.88 on a 1–5 scale) (24 analysts), mean target USD 139.35 (range 111–180).
- Total return with dividends: 1Y +91.9% vs S&P 500 +14.9%; 5Y +99.1% vs S&P 500 +80.3%.
- Next earnings: 2026-10-29, EPS estimate USD -1.27, revenue estimate $2.9M.
Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (KYMR)
| USD | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 | TTM |
|---|---|---|---|---|---|---|
| Revenue | $72.8M | $46.8M | $78.6M | $47.1M | $39.2M | $105M |
| Gross profit | — | $0K | $0K | $0K | $0K | — |
| Operating income | -$101M | -$161M | -$166M | -$262M | -$349M | -$350M |
| Net income | -$100M | -$155M | -$147M | -$224M | -$311M | -$300M |
| EPS (diluted) | -$2.09 | -$2.87 | -$2.52 | -$2.98 | -$3.69 | — |
| Free cash flow | -$131M | -$156M | -$137M | -$207M | -$234M | -$238M |
| Gross margin | — | 0.0% | 0.0% | 0.0% | 0.0% | — |
| Operating margin | -138.0% | -344.4% | -210.6% | -555.8% | -891.1% | -333.5% |
| Net margin | -137.6% | -330.6% | -187.0% | -475.6% | -794.0% | -285.3% |
| Revenue growth | +114.0% | -35.7% | +67.8% | -40.1% | -16.7% | — |
| Cash + short-term investments | $442M | $407M | $375M | $489M | $848M | — |
Fiscal years end Dec. EPS is split-adjusted.
Valuation (price ÷ last four quarters, through Jun 30, 2026) (KYMR)
P/S 86.8x · P/B 6.0x · FCF yield -2.61% · Earnings yield -3.29%
Insider sales (SEC Form 4, open-market, last ~7 months) (KYMR)
22 of 24 under a Rule 10b5-1 trading plan (scheduled in advance). Unplanned sales were timed by the insider.
| Trade date | Insider | Role | Shares | Value | % of holdings sold | 10b5-1 plan | Insider type |
|---|---|---|---|---|---|---|---|
| 2026-10-01 | Mainolfi Nello | Chief Executive Officer | 30,000 | $3.4M | 4.3% | Yes | Too little history (no open-market trades in 2023 or 2024) |
| 2026-09-04 | Adams Brian | Chief Legal Officer | 6,371 | $744K | 11.3% | No | Too little history (no open-market trades in 2023–2025) |
| 2026-07-07 | Mainolfi Nello | Chief Executive Officer | 50,000 | $6.0M | 7% | Yes | Too little history (no open-market trades in 2023 or 2024) |
| 2026-07-01 | Goodman Noah | Chief Business Officer | 3,389 | $387K | 6.7% | Yes | Too little history (no open-market trades in 2023–2025) |
| 2026-07-01 | Mainolfi Nello | Chief Executive Officer | 80,000 | $9.2M | 10.7% | Yes | Too little history (no open-market trades in 2023 or 2024) |
| 2026-06-30 | Jacobs Bruce N. | Chief Financial Officer | 77,109 | $8.9M | 23.9% | Yes | Routine (sold in Mar each year 2023–2025; this trade is outside those months) |
| 2026-06-29 | Booth Bruce | Director | 31,283 | $3.4M | 6.3% | Yes | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-06-26…2026-06-29 | Booth Bruce | Director | 513,245 | $56.5M | 52.4% | Yes | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-06-26 | Bvf Partners L P/il | Director | 1,630,658 | $174M | 83.6% | No | Too little history (no open-market trades in 2024) |
| 2026-06-25 | Booth Bruce | Director | 285,684 | $34.8M | 35% | Yes | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-06-23…2026-06-25 | Booth Bruce | Director | 398,765 | $44.0M | 41.4% | Yes | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-06-25 | Goodman Noah | Chief Business Officer | 5,000 | $570K | 9.1% | Yes | Too little history (no open-market trades in 2023–2025) |
| 2026-06-22 | Booth Bruce | Director | 31,798 | $3.3M | 4.9% | Yes | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-06-17…2026-06-22 | Booth Bruce | Director | 478,198 | $45.3M | 43.6% | Yes (adopted December 16, 2025) | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-06-22 | Goodman Noah | Chief Business Officer | 2,500 | $248K | 4.7% | Yes | Too little history (no open-market trades in 2023–2025) |
| 2026-05-26…2026-05-27 | Chadwick Jeremy G | Chief Operating Officer | 17,184 | $1.4M | 28.1% | Yes | Too little history (no open-market trades in 2023) |
| 2026-05-11 | Ridloff Elena | Director | 3,000 | $261K | 100% | Yes | Too little history (no open-market trades in 2023 or 2024) |
| 2026-04-29 | Mainolfi Nello | Chief Executive Officer | 30,000 | $2.4M | 4.3% | Yes | Too little history (no open-market trades in 2023 or 2024) |
| 2026-04-22 | Booth Bruce | Director | 6,000 | $540K | 0.9% | Yes (adopted December 16, 2025) | Opportunistic (traded every year 2023–2025, no repeating month) |
| 2026-04-22 | Chadwick Jeremy G | Chief Operating Officer | 300 | $27K | 0.5% | Yes | Too little history (no open-market trades in 2023) |
% of holdings sold = shares sold ÷ (shares sold + all holdings the insider reported on that Form 4, direct and through trusts).
Insider type follows Cohen, Malloy & Pomorski (Journal of Finance, 2012). An insider who traded the stock in the same calendar month in each of the past three years is a routine trader; one who traded in each of those years without such a pattern is an opportunistic trader. In their study, trades by opportunistic insiders predicted future returns and trades by routine insiders did not. Counts open-market purchases and sales only (SEC Form 4 codes P and S) by that insider in that company. Not investment advice.
Analysts (KYMR)
Consensus Buy (mean 1.88 on a 1–5 scale), 24 analysts; mean target USD 139.35 (low 111, high 180).
Rating changes, last 120 days:
| Date | Firm | Action | Rating | Price target |
|---|---|---|---|---|
| 2026-10-09 | Raymond James | Initiated | Outperform | $140 |
| 2026-10-05 | Citigroup | Target raised | Buy | $135 → $150 |
| 2026-09-22 | Stifel | Target raised | Buy | $132 → $152 |
| 2026-09-14 | B of A Securities | Target raised | Buy | $123 → $144 |
| 2026-09-10 | Wolfe Research | Upgrade | Peer Perform → Outperform | |
| 2026-08-31 | Guggenheim | Target raised | Buy | $135 → $170 |
| 2026-08-27 | Wells Fargo | Target raised | Overweight | $116 → $151 |
| 2026-08-06 | Barclays | Target raised | Overweight | $133 → $139 |
| 2026-07-30 | Deutsche Bank | Initiated | Hold | $120 |
| 2026-07-28 | Guggenheim | Target raised | Buy | $125 → $135 |
| 2026-07-16 | Mizuho | Target raised | Outperform | $120 → $140 |
| 2026-07-13 | RBC Capital | Downgrade | Outperform → Sector Perform | $106 → $115 |
Total return (dividends reinvested) (KYMR)
| 1Y (from 2025-10-23) | 5Y (from 2021-10-18) | |
|---|---|---|
| Total return | +91.9% | +99.1% |
| S&P 500 (SPY) | +14.9% | +80.3% |
| Per year | +92.3% | +14.7% |
| Volatility (annualized) | 57.8% | 72.8% |
| Max drawdown | -27.7% (Dec 2025→Jan 2026) | -83.1% (Nov 2021→Oct 2023) |
KYMR suppliers, customers and competitors (named in its 10-K)
| Relationship | Company | Sentence in the filing |
|---|---|---|
| Customer | Jefferies | “Sales to, or through, Jefferies by us could result in substantial dilution to the interests of other holders of our common stock.” |
| Partner | Sanofi (SNY) | “We are collaborating with Sanofi S.A. ("Sanofi") on the development of our IRAK4 degrader, KT-485/SAR447971, which Sanofi plans to advance into clinical testing in 2026.” |
| Partner | GILEAD SCIENCES, INC. (GILD) | “In June 2025, we announced a strategic collaboration with Gilead Sciences, Inc. ("Gilead") to develop novel oral molecular glue degraders for CDK2.” |
| Partner | Vertex Pharmaceuticals | “Our only revenues have been derived from research collaboration arrangements with Vertex Pharmaceuticals Incorporated, or Vertex,, Sanofi and Gilead.” |
| Partner | Johnson & Johnson (JNJ) | “In particular, several pharmaceutical companies have announced partnerships around programs targeting STAT6, and/or have their own internal STAT6 programs, including Gilead Sciences, Inc, Johnson & Johnson, Pfizer and Sanofi.” |
| Partner | Cowen and Company | “To date, we have received gross proceeds of $2.75 billion from sales of our convertible preferred stock, the sale of common stock including our August 2020 initial public offering, or IPO, and concurrent private placement, our subsequent follow-on offerings and private placement offering, our prior sales agreement with Cowen and through our corporate collaborations.” |
| Partner | Pfizer (PFE) | “In particular, several pharmaceutical companies have announced partnerships around programs targeting STAT6, and/or have their own internal STAT6 programs, including Gilead Sciences, Inc, Johnson & Johnson, Pfizer and Sanofi.” |
Quoted from the company's 10-K filed Feb 26, 2026.
Companies that name KYMR in their SEC reports
| Relationship to KYMR | Company | Filing | Sentence |
|---|---|---|---|
| partner | GILEAD SCIENCES, INC. (GILD) | 10-K Feb 24, 2026 | “•Entered into an exclusive option and license agreement with Kymera Therapeutics, Inc. to develop novel oral molecular glue CDK2 degraders with broad oncology treatment potential.” |
KYMR company outlook (results filed Aug 5, 2026)
- “The accelerated timeline enables us to pull forward our expected topline readout to year-end 2026, positions us for an earlier than anticipated start to Phase 3 trials next year, and ultimately allows us to move faster for patients who are waiting for new options." Dr.”
- “The earlier than expected completion of enrollment enabled the Company to accelerate its expected topline data readout by six months to year-end 2026, earlier than prior guidance to share data by mid-2027.”
- “Subject to discussions with regulators, the Company expects to initiate Phase 3 trials in AD by mid-2027. • Enrollment is ongoing in the KT-621 BREADTH Phase 2b clinical trial in patients with moderate to severe eosinophilic asthma.”
- “The Company expects to report data in late 2027. • In June 2026 at the Japanese Dermatological Association (JDA) Annual Meeting, the Company presented results from the KT-621 Phase 1 study in healthy Japanese adults designed to support the enrollment of patients in Japan in global KT-621 studies.”
Quoted word-for-word from the SEC 8-K results press release.
KYMR analyst estimates and revisions
| Period | EPS estimate | 90 days ago | Change | Revenue estimate | Analysts |
|---|---|---|---|---|---|
| Current quarter (ends Sep 2026) | $-1.27 | $-1.03 | +23.3% | $2.9M | 21 |
| Next quarter (ends Dec 2026) | $-1.25 | $-1.03 | +21.9% | $3.3M | 21 |
| Current fiscal year (ends Dec 2026) | $-3.85 | $-3.51 | +9.6% | $104.8M | 21 |
| Next fiscal year (ends Dec 2027) | $-5.10 | $-4.35 | +17.2% | $40.7M | 21 |
KYMR options: expected move
Options price a move of about ±24.6% (±$27.25) by Nov 20, 2026, which includes earnings on Oct 29, 2026. Over the last 8 reports the stock moved ±3.1% on average.
| Expiration | Days | ATM implied volatility | Expected move |
|---|---|---|---|
| Nov 20, 2026 | 28 | 110.1% | ±24.6% |
| Dec 18, 2026 | 56 | 168.0% | ±51.7% |
| Jan 15, 2027 | 84 | 147.0% | ±55.0% |
| Feb 19, 2027 | 119 | 128.1% | ±56.8% |
| Mar 19, 2027 | 147 | 118.5% | ±58.2% |
| May 21, 2027 | 210 | 104.9% | ±61.2% |
30-day implied volatility 109.6% vs 40.3% realized over the last 30 trading days. Put/call ratio (volume) 1.6. Cboe delayed quotes (15 min). Expected move = at-the-money straddle.
Key Statistics (as of October 23, 2026 at 10:04 UTC)
| Price | USD 110.85 |
|---|---|
| Change | ▼ 1.58% (down) |
| Previous Close | USD 112.63 |
| Open | USD 111.43 |
| Day Range | USD 110.16 – 113.73 |
| 52-Week Range | USD 55.26 – 130.05 |
| Volume | 850,259 shares |
| Market Cap | $9.12B |
| Exchange | NGM |
Technical Analysis (KYMR)
Nexqual's technical model rates KYMR "NEUTRAL" based on 2 bullish and 3 bearish signals across 127 daily candles, as of October 23, 2026 at 10:04 UTC.
| Overall Signal | NEUTRAL |
|---|---|
| RSI (14) | 49.08 (neutral) |
| vs SMA50 | Below (USD 115.09) |
| MACD | -1.06 (negative) |
Analyst Ratings (KYMR)
Wall Street analysts rate KYMR "Buy" based on 24 analysts, with a mean price target of USD 139.35 (range USD 111–180), per Nexqual as of October 23, 2026 at 10:04 UTC.
| Consensus Rating | Buy |
|---|---|
| Analyst Count | 24 |
| Mean Target | USD 139.35 |
| High Target | USD 180 |
| Low Target | USD 111 |
| Buy / Hold / Sell | 22 / 2 / 0 |
Earnings (KYMR)
| Next Earnings Date | 2026-10-29 |
|---|---|
| EPS Estimate | USD -1.27 |
| Revenue Estimate | $2.95M |
Recent Earnings History
| Quarter | Actual vs Estimate |
|---|---|
| 2026-06-30 | USD -0.62 vs est -0.74 ▲ beat |
| 2026-03-31 | USD -0.71 vs est -0.86 ▲ beat |
| 2025-12-31 | USD -0.98 vs est -0.77 ▼ miss |
| 2025-09-30 | USD -0.94 vs est -0.78 ▼ miss |
Source: Nexqual, October 23, 2026 at 10:04 UTC.
Financials & Fundamentals (KYMR)
| Total Revenue | $105.00M |
|---|---|
| Revenue Growth (latest quarter, YoY) | +466.40% |
| Gross Margin | -257.69% |
| Operating Margin | -116.32% |
| Profit Margin | -285.33% |
| ROE | -24.15% |
| Debt / Equity | 0.05 |
| Current Ratio | 10.34 |
| Total Cash | $690.99M |
| Total Debt | $78.56M |
| Free Cash Flow (last four quarters to Jun 2026, SEC 10-Q / 10-K) | -$237.96M (-226.6% of revenue) |
Source: Nexqual, October 23, 2026 at 10:04 UTC.
Financial Health Score (KYMR)
Nexqual rates Kymera Therapeutics, Inc.'s overall financial health "Weak" across five dimensions, as of October 23, 2026 at 10:04 UTC.
| Growth | Critical — Revenue -17% YoY (annual), sharp decline |
|---|---|
| Profitability | Weak — Small revenue base — building scale |
| Balance Sheet | Strong — $691M cash vs $79M debt, net cash position |
| Cash Flow | Weak — FCF negative: -$238M (last 4 quarters to Jun 2026, SEC), burning cash |
| Efficiency | Critical — ROE -24%, ROA -15.6% |
Ownership (KYMR)
| Insider Ownership | +2.12% |
|---|---|
| Institutional Ownership | +119.39% |
| Shares Outstanding | 82.26M |
| Float | 66.04M |
| Short % of Float | +15.33% |
Source: Nexqual, October 23, 2026 at 10:04 UTC.
Leadership (KYMR)
Kymera Therapeutics, Inc. is led by Nello Mainolfi, Co-Founder, President, CEO & Director, per Nexqual as of October 23, 2026 at 10:04 UTC.
| Co-Founder, President, CEO & Director | Nello Mainolfi |
|---|---|
| Chief Financial Officer | Bruce N. Jacobs |
| Vice President of Investor Relations | Justine E. Koenigsberg |
Major Backers & Investors (KYMR)
Notable institutional backers of Kymera Therapeutics, Inc. include FMR, LLC, Baker Bros. Advisors, LP, Avoro Capital Advisors LLC, according to Nexqual as of October 23, 2026 at 10:04 UTC.
Active Investors
| Investor | Stake |
|---|---|
| FMR, LLC | 14.85% |
| Baker Bros. Advisors, LP | 10.41% |
| Avoro Capital Advisors LLC | 8.99% |
| Price (T.Rowe) Associates Inc | 8.55% |
| T. Rowe Price | 7.53% |
| BVF Inc. | 4.66% |
| Wellington Management | 4.42% |
| Siren, L.L.C. | 3.53% |
Index Funds (Passive)
| Fund | Stake |
|---|---|
| BlackRock | 6.66% |
| Vanguard Group | 3.6% |
Source: Nexqual, October 23, 2026 at 10:04 UTC.
From Kymera Therapeutics, Inc.'s Latest SEC 10-K Filing (filed 2026-02-26)
Key Strengths & Strategy (as disclosed to the SEC)
- Our approach to target selection and our proprietary drug discovery capabilities enable us to rationally design innovative medicines that ultimately have the potential to address disease-causing proteins of all classes.
- We have developed a broad patent estate and expect to expand and protect our proprietary know-how and intellectual property.
- We seek to protect our proprietary technology, in part, through confidentiality agreements and invention assignment agreements with our employees, consultants, scientific advisors, contractors and potential collaborators.
- Our success also depends on our ability to defend and enforce our intellectual property rights, preserve the confidentiality of our proprietary information, and operate without infringing, misappropriating or otherwise violating the valid and enforceable patents and proprietary rights of third parties.
Partnerships
- On November 15, 2022, we entered into an Amended and Restated Collaboration and License Agreement with Sanofi, or the Amended Sanofi Agreement, which amended the Original Sanofi Agreement to revise certain research terms and responsibilities set forth under the Original Sanofi Agreement.
- In June 2025, we announced a strategic collaboration with Gilead Sciences, Inc. ("Gilead") to develop novel oral molecular glue degraders for CDK2.
Legal & Regulatory Risks (Item 1A, quoted)
- Risks Related to Preclinical and Clinical Development
- We may not be successful in our efforts to identify or discover additional product candidates or we may expend our limited resources to pursue a particular product candidate or indication and fail to capitalize on product candidates or indications that may be more profitable or for which there is a greater likelihood of success.
- We currently have no product candidates approved for sale and may never be able to develop marketable product candidates.
- Any of these factors, many of which are beyond our control, could jeopardize our ability to obtain regulatory approval for and successfully market our current or future product candidates.
Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.
Peers & Related Stocks
| Symbol | Name | Price | Change |
|---|---|---|---|
| IBRX | ImmunityBio, Inc. | USD 8.31 | ▼ 3.82% |
| CAI | Caris Life Sciences, Inc. | USD 31.71 | ▼ 1.98% |
| KRYS | Krystal Biotech, Inc. | USD 320.13 | ▼ 0.63% |
| PTGX | Protagonist Therapeutics, Inc. | USD 139.53 | ▲ 1.05% |
| CYTK | Cytokinetics, Incorporated | USD 62.33 | ▼ 0.84% |
| SYRE | Spyre Therapeutics, Inc. | USD 92.33 | ▼ 0.67% |
Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 23, 2026 at 10:04 UTC. This page is informational and not investment advice.
For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt