MeiraGTx Holdings plc (MGTX) Stock Price & Analysis
MeiraGTx Holdings plc (MGTX) is trading at USD 9.78, up 0.26% today, as of October 29, 2026 at 16:06 UTC (US market open; quotes may be delayed), according to Nexqual market data.
MGTX last closed at USD 9.75; today's session has ranged USD 9.58–9.9 on volume of 100,293 shares. Market capitalization is $938.82M, with a 52-week range of USD 6.62–15.35 (NMS). Source: Nexqual, retrieved October 29, 2026 at 16:07 UTC.
Also available as compact Markdown for AI agents: nexqual.com/MGTX.md
Key facts (MGTX)
- Last four reported quarters (through Jun 30, 2026): revenue $398M, net income $79.0M (19.9% margin), free cash flow $10.5M (SEC filings).
- Valuation: P/E 11.9x, EV/EBITDA 4.6x, net cash $43.2M.
- Insider open-market sales, last ~7 months: 7 Form 4 filings, $4.0M; 0 not under a Rule 10b5-1 plan ($0K); 0 by opportunistic insiders, 0 by routine insiders (three-year test, Cohen, Malloy & Pomorski 2012).
- Analysts: Buy (mean 1.88 on a 1–5 scale) (8 analysts), mean target USD 27.75 (range 16–50).
- Total return with dividends: 1Y +9.5% vs S&P 500 +13.2%; 5Y -54.5% vs S&P 500 +79.2%.
- Next earnings: 2026-11-12, EPS estimate USD -0.47, revenue estimate $7.0M.
Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (MGTX)
| USD | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 | TTM |
|---|---|---|---|---|---|---|
| Revenue | $37.7M | $15.9M | $14.0M | $33.3M | $81.4M | $398M |
| Operating income | -$72.8M | -$116M | -$137M | -$164M | -$106M | $184M |
| Net income | -$79.6M | -$130M | -$84.0M | -$148M | -$114M | $79.0M |
| EPS (diluted) | -$1.80 | -$2.87 | -$1.49 | -$2.12 | -$1.42 | — |
| Free cash flow | -$56.9M | -$118M | -$126M | -$109M | -$50.2M | $10.5M |
| Operating margin | -193.0% | -730.9% | -977.8% | -493.4% | -130.2% | 46.3% |
| Net margin | -211.0% | -814.2% | -599.5% | -444.1% | -140.3% | 19.9% |
| Revenue growth | +142.2% | -57.8% | -12.0% | +137.4% | +144.6% | — |
| Cash + short-term investments | $138M | $116M | $130M | $104M | $65.9M | — |
| Total debt | — | $71.0M | $72.1M | $73.2M | $49.7M | — |
Fiscal years end Dec. EPS is split-adjusted.
Valuation (price ÷ last four quarters, through Jun 30, 2026) (MGTX)
P/E 11.9x · P/S 2.4x · EV/EBITDA 4.6x · EV/Sales 2.3x · P/FCF 89.7x · P/B 4.3x · FCF yield 1.11% · Earnings yield 8.41% · Net cash $43.2M · EV $896M
Insider sales (SEC Form 4, open-market, last ~7 months) (MGTX)
7 of 7 under a Rule 10b5-1 trading plan (scheduled in advance). Unplanned sales were timed by the insider.
| Trade date | Insider | Role | Shares | Value | % of holdings sold | 10b5-1 plan | Insider type |
|---|---|---|---|---|---|---|---|
| 2026-10-20 | Giroux Richard | CFO & COO | 56,000 | $557K | 5.6% | Yes (adopted November 18, 2025) | Too little history (no open-market trades in 2023 or 2024) |
| 2026-10-06 | Naylor Stuart | CHIEF SCI OFCR, OPHTHALMOLOGY | 27,659 | $294K | 4.3% | Yes (adopted December 9, 2025) | Too little history (no open-market trades in 2023–2025) |
| 2026-08-18 | Forbes Alexandria | PRESIDENT & CEO | 62,000 | $859K | 4.5% | Yes (adopted November 18, 2025) | Too little history (no open-market trades in 2023 or 2024) |
| 2026-07-21 | Giroux Richard | CFO & COO | 56,000 | $701K | 5.3% | Yes (adopted November 18, 2025) | Too little history (no open-market trades in 2023 or 2024) |
| 2026-07-07 | Naylor Stuart | CHIEF SCI OFCR, OPHTHALMOLOGY | 27,659 | $409K | 4.1% | Yes (adopted December 9, 2025) | Too little history (no open-market trades in 2023–2025) |
| 2026-05-19 | Forbes Alexandria | PRESIDENT & CEO | 62,000 | $569K | 4.3% | Yes (adopted November 18, 2025) | Too little history (no open-market trades in 2023 or 2024) |
| 2026-04-21 | Giroux Richard | CFO & COO | 56,000 | $572K | 5% | Yes (adopted November 18, 2025) | Too little history (no open-market trades in 2023 or 2024) |
% of holdings sold = shares sold ÷ (shares sold + all holdings the insider reported on that Form 4, direct and through trusts).
Insider type follows Cohen, Malloy & Pomorski (Journal of Finance, 2012). An insider who traded the stock in the same calendar month in each of the past three years is a routine trader; one who traded in each of those years without such a pattern is an opportunistic trader. In their study, trades by opportunistic insiders predicted future returns and trades by routine insiders did not. Counts open-market purchases and sales only (SEC Form 4 codes P and S) by that insider in that company. Not investment advice.
Analysts (MGTX)
Consensus Buy (mean 1.88 on a 1–5 scale), 8 analysts; mean target USD 27.75 (low 16, high 50).
Rating changes, last 120 days:
| Date | Firm | Action | Rating | Price target |
|---|---|---|---|---|
| 2026-09-24 | Goldman Sachs | Initiated | Neutral | $16 |
| 2026-08-14 | RBC Capital | Target raised | Outperform | $26 → $27 |
| 2026-07-08 | RBC Capital | Target raised | Outperform | $25 → $26 |
| 2026-07-08 | HC Wainwright & Co. | Reiterated | Buy | $20 |
Total return (dividends reinvested) (MGTX)
| 1Y (from 2025-10-29) | 5Y (from 2021-10-25) | |
|---|---|---|
| Total return | +9.5% | -54.5% |
| S&P 500 (SPY) | +13.2% | +79.2% |
| Per year | +9.5% | -14.6% |
| Volatility (annualized) | 57.5% | 69.4% |
| Max drawdown | -38.7% (Aug 2026→Oct 2026) | -84.4% (Dec 2021→Oct 2023) |
MGTX earnings history and stock reaction
| Results filed | Quarter | EPS | Consensus | Surprise | Stock reaction |
|---|---|---|---|---|---|
| Aug 13, 2026 | Quarter ended Jun 30, 2026 | $2.52 | −$0.42 | Beat +$2.94 | +4.3% |
| May 14, 2026 | Quarter ended Mar 31, 2026 | −$0.57 | −$0.45 | Miss −26.7% | -5.7% |
| Mar 26, 2026 | Quarter ended Dec 31, 2025 | $0.19 | −$0.62 | Beat +$0.81 | +0.0% |
| Nov 13, 2025 | Quarter ended Sep 30, 2025 | −$0.62 | −$0.49 | Miss −26.5% | -5.4% |
| Aug 14, 2025 | — | — | — | — | -2.0% |
| May 13, 2025 | — | — | — | — | -17.5% |
| Mar 13, 2025 | — | — | — | — | +21.5% |
| Nov 13, 2024 | — | — | — | — | -0.3% |
EPS as reported against the analyst consensus before the release; surprise uses the cent-rounded figures shown (in dollars when EPS and consensus have opposite signs). Stock reaction = close before the results to close after (the first close following a release after the bell or before the open).
MGTX recent SEC filings (last 120 days)
| Filed | Form | What it says |
|---|---|---|
| Sep 23, 2026 | 8-K | Director or executive officer change, or pay arrangement; Regulation FD disclosure “On September 22, 2026, the Board of Directors (the "Board") of MeiraGTx Holdings plc (the "Company"), upon the recommendation of its Nominating and Corporate Governance Committee, appointed Alan M. Sebulsky to the Board as a Class I director, effective September 23, 2026, with a term that expires at the Company's 2028 annual meeting of shareholders when Class I directors are up for re-election and until his successor is duly elected and qualified. Mr. Sebulsky has been appointed to serve as a member of the Science…” |
| Aug 14, 2026 | Schedule 13G/A | Rubric Capital Management LP, David Rosen: 9.8% of shares, passive 5%+ holder (amended) |
| Aug 13, 2026 | 10-Q | Quarterly report · period ended Jun 30, 2026 |
| Aug 13, 2026 | 8-K | Quarterly results |
| Jul 7, 2026 | 8-K | Entered a material agreement; Ended a material agreement; New debt or off-balance-sheet obligation; Unregistered sale of shares; Regulation FD disclosure “Royalty Note Purchase Agreement On June 30, 2026, MeiraGTx Holdings plc (the "Company") and certain of its subsidiaries entered into a Royalty Note Purchase Agreement (the "Royalty Note Purchase Agreement"), by and among MeiraGTx, LLC, as issuer, the Company and certain of its subsidiaries, as obligors (collectively, together with the Company, the "Obligors"), the purchasers party thereto (the "Purchasers") and Maverick SA LLC, as purchaser agent, an affiliate of funds managed by Oberland Capital Management LLC…” |
Source: SEC EDGAR. Quotes are the opening words of each item as filed; each form links to the filing. Insider Form 4 filings are listed in the insider sections.
MGTX suppliers, customers and competitors (named in its 10-K)
| Relationship | Company | Sentence in the filing |
|---|---|---|
| Partner | Johnson & Johnson (JNJ) | “On January 30, 2019, we and our wholly-owned subsidiary MeiraGTx UK II Limited entered into a Collaboration, Option and License Agreement with Johnson & Johnson Innovative Medicine (formerly known as Janssen Pharmaceuticals, Inc.), as further amended by that certain First Amendment to Collaboration, Option and License Agreement, dated as of December 16, 2021 (the "Collaboration Agreement"), for, among other things…” |
| Partner | Eli Lilly (LLY) | “On November 7, 2025 (the "Effective Date"), our affiliates MeiraGTx Ocular UK Limited ("MeiraGTx Ocular"), MeiraGTx Limited and MeiraGTx UK II Limited, entered into a strategic collaboration and license agreement with Eli Lilly and Company ("Lilly") (the "Lilly Collaboration Agreement") for the research, development and commercialization of genetic medicines in and related to the area of ophthalmology.” |
| Partner | Hologen | “As part of the strategic collaboration, we also received an aggregate of 500,000 Class A shares of Hologen at a nominal price.” |
| Partner | MeiraGTx Neuro UK | “On the Hologen Closing Date, under the Hologen Collaboration Agreement, MeiraGTx Neuro US will have received the applicable portion of the Upfront Payment in consideration for granting to Hologen Neuro and Hologen Neuro UK, as of the Hologen Closing Date and subject to the license granted by Hologen Neuro and Hologen Neuro UK back to MeiraGTx Neuro UK, exclusive, worldwide, royalty-free, fully paid-up licenses to …” |
| Partner | MeiraGTx UK II | “In connection with entering into the Asset Purchase Agreement, we and MeiraGTx UK II Limited entered into a Termination Agreement with Johnson & Johnson Innovative Medicine on the Closing Date terminating the Collaboration Agreement.” |
| Partner | BofA Securities | “In December 2023, we entered into an "at-the-market" sales agreement with BofA Securities, Inc., or BofA, pursuant to which we may sell from time to time, ordinary shares having an aggregate offering price of up to $100.0 million through BofA, acting as our agent.” |
| Partner | AMD (AMD) | “The First UCLB License Agreement had also included an option to the dry AMD gene therapy program.” |
Quoted from the company's 10-K filed Mar 30, 2026.
Companies that name MGTX in their SEC reports
| Relationship to MGTX | Company | Filing | Sentence |
|---|---|---|---|
| partner | Ocugen, Inc. (OCGN) | 10-K Mar 4, 2026 | “We are aware of several companies focusing on gene therapies for various ophthalmic indications including Applied Genetic Technologies Corporation, as acquired by Beacon Therapeutics, Astellas Pharma Inc., MeiraGTx Holdings plc in partnership with Janssen Pharmaceuticals, Inc., Nanoscope Therapeutics Inc., REGENXBIO Inc., Novartis AG, F.” |
MGTX analyst estimates and revisions
| Period | EPS estimate | 90 days ago | Change | Revenue estimate | Analysts |
|---|---|---|---|---|---|
| Current quarter (ends Sep 2026) | $-0.47 | $-0.50 | +$0.03 | $7.0M | 3 |
| Next quarter (ends Dec 2026) | $-0.50 | $-0.27 | −$0.23 | $8.5M | 3 |
| Current fiscal year (ends Dec 2026) | $0.51 | $-1.47 | +$1.98 | $337.1M | 3 |
| Next fiscal year (ends Dec 2027) | $-1.52 | $-1.39 | −$0.13 | $66.9M | 4 |
MGTX options: expected move
Options price a move of about ±50.3% (±$4.80) by Nov 20, 2026, which includes earnings on Nov 12, 2026. Over the last 8 reports the stock moved ±7.1% on average.
| Expiration | Days | ATM implied volatility | Expected move |
|---|---|---|---|
| Nov 20, 2026 | 22 | 166.7% | ±50.3% |
| Dec 18, 2026 | 50 | 130.7% | ±39.8% |
| Jan 15, 2027 | 78 | 149.1% | ±56.6% |
| Apr 16, 2027 | 169 | 108.6% | ±60.2% |
30-day implied volatility 95% vs 53.3% realized over the last 30 trading days. Put/call ratio (volume) 0. Cboe delayed quotes (15 min). Expected move = at-the-money straddle.
Key Statistics (as of October 29, 2026 at 16:07 UTC)
| Price | USD 9.78 |
|---|---|
| Change | ▲ 0.26% (up) |
| Previous Close | USD 9.75 |
| Open | USD 9.79 |
| Day Range | USD 9.58 – 9.9 |
| 52-Week Range | USD 6.62 – 15.35 |
| Volume | 100,293 shares |
| Market Cap | $938.82M |
| Exchange | NMS |
Technical Analysis (MGTX)
Nexqual's technical model rates MGTX "STRONG SELL" based on 0 bullish and 5 bearish signals across 128 daily candles, as of October 29, 2026 at 16:07 UTC.
| Overall Signal | STRONG SELL |
|---|---|
| RSI (14) | 39.86 (neutral) |
| vs SMA50 | Below (USD 11.82) |
| MACD | -0.6 (negative) |
Analyst Ratings (MGTX)
Wall Street analysts rate MGTX "Buy" based on 8 analysts, with a mean price target of USD 27.75 (range USD 16–50), per Nexqual as of October 29, 2026 at 16:07 UTC.
| Consensus Rating | Buy |
|---|---|
| Analyst Count | 8 |
| Mean Target | USD 27.75 |
| High Target | USD 50 |
| Low Target | USD 16 |
| Buy / Hold / Sell | 7 / 1 / 0 |
Earnings (MGTX)
| Next Earnings Date | 2026-11-12 |
|---|---|
| EPS Estimate | USD -0.47 |
| Revenue Estimate | $7.02M |
Recent Earnings History
| Quarter | Actual vs Estimate |
|---|---|
| 2026-06-30 | USD 2.52 vs est -0.42 ▲ beat |
| 2026-03-31 | USD -0.57 vs est -0.45 ▼ miss |
| 2025-12-31 | USD 0.19 vs est -0.62 ▲ beat |
| 2025-09-30 | USD -0.62 vs est -0.49 ▼ miss |
Source: Nexqual, October 29, 2026 at 16:07 UTC.
Financials & Fundamentals (MGTX)
| Total Revenue | $397.50M |
|---|---|
| Revenue Growth (latest quarter, YoY) | +8608.60% |
| Gross Margin | +97.95% |
| Operating Margin | +76.04% |
| Profit Margin | +19.87% |
| ROE | +72.17% |
| Debt / Equity | 0.52 |
| Current Ratio | 3.76 |
| Total Cash | $143.17M |
| Total Debt | $112.32M |
| Free Cash Flow (last four quarters to Jun 2026, SEC 10-Q / 10-K) | $10.47M (2.6% of revenue) |
Source: Nexqual, October 29, 2026 at 16:07 UTC.
Financial Health Score (MGTX)
Nexqual rates MeiraGTx Holdings plc's overall financial health "Strong" across five dimensions, as of October 29, 2026 at 16:07 UTC.
| Growth | Strong — Revenue +145% YoY (annual) |
|---|---|
| Profitability | Strong — Operating margin 46% |
| Balance Sheet | Strong — $143M cash and investments vs $100M debt (Jun 2026, SEC), net cash |
| Cash Flow | Mixed — FCF $10M (last 4 quarters to Jun 2026, SEC), slim 2.6% margin |
| Efficiency | Strong — ROE 37%, ROA 19.9% (last 4 quarters, SEC) |
Ownership (MGTX)
| Insider Ownership | +16.27% |
|---|---|
| Institutional Ownership | +70.78% |
| Shares Outstanding | 96.04M |
| Float | 53.83M |
| Short % of Float | +9.35% |
Source: Nexqual, October 29, 2026 at 16:07 UTC.
Leadership (MGTX)
MeiraGTx Holdings plc is led by Alexandria Forbes, CEO, President & Director, per Nexqual as of October 29, 2026 at 16:07 UTC.
| CEO, President & Director | Alexandria Forbes |
|---|---|
| COO & CFO | Richard Brian Giroux B.A. |
| Chief Scientific Officer of Ophthalmology | Stuart Naylor |
| Senior Vice President of Global Integration | Christine Elise Sheehy |
| Senior Vice President of Risk & Internal Controls | Tim Randall |
Major Backers & Investors (MGTX)
Notable institutional backers of MeiraGTx Holdings plc include Sanofi, Perceptive Advisors Llc, Rubric Capital Management LP, according to Nexqual as of October 29, 2026 at 16:07 UTC.
Active Investors
| Investor | Stake |
|---|---|
| Sanofi | 12.7% |
| Perceptive Advisors Llc | 11.23% |
| Rubric Capital Management LP | 9.47% |
| Johnson & Johnson | 6.91% |
| Adage Capital Partners GP L.L.C. | 4.58% |
| Opaleye Management Inc. | 3.7% |
| Millennium Management | 3.09% |
| 683 Capital Management LLC | 2.39% |
Index Funds (Passive)
| Fund | Stake |
|---|---|
| BlackRock | 4.95% |
Source: Nexqual, October 29, 2026 at 16:07 UTC.
From MeiraGTx Holdings plc's Latest SEC 10-K Filing (filed 2026-03-30)
Key Strengths & Strategy (as disclosed to the SEC)
- We are a vertically integrated, clinical-stage genetic medicines company with a broad pipeline of late-stage clinical programs, including radiation-induced xerostomia, Parkinson's disease and AIPL1-associated retinal dystrophy.
- During 2024, we gained alignment with the FDA on requirements for the Phase 2 AQUAx2 clinical trial to be considered a pivotal trial in support of a potential Biologics License Application, or BLA, filing.
- The successful development of the clinical pipeline is supported by our internal end-to-end manufacturing capabilities.
- Lilly also has a right of first negotiation for use of our proprietary riboswitch technology in the field of ophthalmological gene editing.
Partnerships
- We entered into a strategic collaboration with Lilly in the area of ophthalmology, including granting Lilly worldwide exclusive rights to our AAV-AIPL1 program for the treatment of patients with Leber congenital amaurosis 4, or LCA4, caused by mutations in the AIPL1 gene.
- On November 7, 2025 (the "Effective Date"), our affiliates MeiraGTx Ocular UK Limited ("MeiraGTx Ocular"), MeiraGTx Limited and MeiraGTx UK II Limited, entered into a strategic collaboration and license agreement with Eli Lilly and Company ("Lilly") (the "Lilly Collaboration Agreement") for the research, development and commercialization of genetic medicines in and related to the area of ophthalmology.
Legal & Regulatory Risks (Item 1A, quoted)
- We may not have sufficient cash flows or cash on hand to satisfy our debt obligations or covenants under our financing arrangements, or we may not be able to effectively manage our business in compliance with such covenants.
- We are heavily dependent on the success of our product candidates, which are still in development, and if none of them receive regulatory approval or are successfully commercialized, our business may be harmed.
- Risks Related to Discovery, Development, Clinical Testing, Manufacturing and Regulatory Approval
- We and our contract manufacturers for plasmid are subject to significant regulation with respect to manufacturing our products. Our manufacturing facilities and the third-party manufacturing facilities which we rely on may not continue to meet regulatory requirements and have limited capacity.
Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.
Peers & Related Stocks
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| IOVA | Iovance Biotherapeutics, Inc. | USD 9.45 | ▼ 36.23% |
| IONS | Ionis Pharmaceuticals, Inc. | USD 45.08 | ▲ 0.4% |
| AXSM | Axsome Therapeutics, Inc. | USD 144.54 | ▲ 0.72% |
| ABVX | Abivax SA | USD 90.7 | ▲ 0.96% |
Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 29, 2026 at 16:07 UTC. This page is informational and not investment advice.
For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt