Tango Therapeutics, Inc. (TNGX) Stock Price & Analysis

Tango Therapeutics, Inc. (TNGX) closed at USD 22.23 on Wednesday, October 28, 2026, down 2.88% on the day. The US market is currently closed (pre-market); this is not a live price.

The prior close was USD 22.89; the Oct 28, 2026 session ranged USD 22.14–23.71 on volume of 3,309,657 shares. Market capitalization is $3.75B, with a 52-week range of USD 7.37–34.39 (NGM). Source: Nexqual, retrieved October 29, 2026 at 08:45 UTC.

Also available as compact Markdown for AI agents: nexqual.com/TNGX.md

Key facts (TNGX)

Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (TNGX)

USDFY2021FY2022FY2023FY2024FY2025TTM
Revenue$37.0M$24.9M$36.5M$42.1M$62.4M$53.8M
Operating income-$58.2M-$111M-$114M-$146M-$111M-$136M
Net income-$58.2M-$108M-$102M-$130M-$102M-$124M
EPS (diluted)-$0.94-$1.23-$1.08-$1.19-$0.87—
Free cash flow-$61.4M-$117M-$120M-$132M-$140M-$144M
Operating margin-157.1%-446.8%-312.6%-346.1%-178.4%-253.4%
Net margin-157.2%-435.1%-278.5%-309.7%-162.9%-229.9%
Revenue growth+383.8%-32.9%+46.9%+15.2%+48.3%—
Cash + short-term investments$485M$366M$337M$258M$343M—

Fiscal years end Dec. EPS is split-adjusted.

Valuation (price ÷ last four quarters, through Jun 30, 2026) (TNGX)

P/S 69.7x · P/B 3.7x · FCF yield -3.85% · Earnings yield -3.30%

Insider sales (SEC Form 4, open-market, last ~7 months) (TNGX)

8 of 8 under a Rule 10b5-1 trading plan (scheduled in advance). Unplanned sales were timed by the insider.

Trade dateInsiderRoleSharesValue% of holdings sold10b5-1 planInsider type
2026-10-01Crystal AdamPresident, R&D27,000$661K18.9%Yes (adopted October 27, 2025)Opportunistic (traded every year 2023–2025, no repeating month)
2026-09-22Newcomb JessicaPrincipal Accounting Officer8,200$199K12.2%Yes (adopted June 23, 2026)Too little history (no open-market trades in 2023–2025)
2026-09-01Crystal AdamPresident, R&D27,000$604K18.9%Yes (adopted October 27, 2025)Opportunistic (traded every year 2023–2025, no repeating month)
2026-08-03Crystal AdamPresident, R&D27,000$736K18.9%Yes (adopted October 27, 2025)Opportunistic (traded every year 2023–2025, no repeating month)
2026-07-01Crystal AdamPresident, R&D27,000$799K18.9%Yes (adopted October 27, 2025)Opportunistic (traded every year 2023–2025, no repeating month)
2026-06-01Crystal AdamPresident, R&D27,000$618K18.9%Yes (adopted October 27, 2025)Opportunistic (traded every year 2023–2025, no repeating month)
2026-05-01Crystal AdamPresident, R&D27,000$573K18.9%Yes (adopted October 27, 2025)Opportunistic (traded every year 2023–2025, no repeating month)
2026-04-15Crystal AdamPresident, R&D38,460$962K25.5%Yes (adopted October 27, 2025)Opportunistic (traded every year 2023–2025, no repeating month)

% of holdings sold = shares sold ÷ (shares sold + all holdings the insider reported on that Form 4, direct and through trusts).

Insider type follows Cohen, Malloy & Pomorski (Journal of Finance, 2012). An insider who traded the stock in the same calendar month in each of the past three years is a routine trader; one who traded in each of those years without such a pattern is an opportunistic trader. In their study, trades by opportunistic insiders predicted future returns and trades by routine insiders did not. Counts open-market purchases and sales only (SEC Form 4 codes P and S) by that insider in that company. Not investment advice.

Analysts (TNGX)

Consensus Buy (mean 2.00 on a 1–5 scale), 13 analysts; mean target USD 47.09 (low 24, high 69).

Rating changes, last 120 days:

DateFirmActionRatingPrice target
2026-10-16William BlairInitiatedOutperform
2026-08-18HC Wainwright & Co.Target raisedBuy$66 → $68
2026-08-12GuggenheimTarget raisedBuy$32 → $35
2026-07-17MizuhoTarget raisedOutperform$36 → $40
2026-07-15JP MorganInitiatedOverweight$46

TNGX earnings history and stock reaction

Results filedQuarterEPSConsensusSurpriseStock reaction
—Quarter ended Jun 30, 2026−$0.37−$0.32Miss −15.6%—
—Quarter ended Mar 31, 2026−$0.32−$0.31Miss −3.2%—
—Quarter ended Dec 31, 2025−$0.29−$0.33Beat +12.1%—
—Quarter ended Sep 30, 2025$0.13−$0.07Beat +$0.20—

EPS as reported against the analyst consensus before the release; surprise uses the cent-rounded figures shown (in dollars when EPS and consensus have opposite signs). Stock reaction = close before the results to close after (the first close following a release after the bell or before the open).

TNGX recent SEC filings (last 120 days)

FiledFormWhat it says
Oct 23, 20268-KRegulation FD disclosure; Other material event
“Promising Results from Phase 1/2 Clinical Trial of Vopimetostat in Combination with RAS(ON) Inhibitors On October 23, 2026, the Company disclosed promising results from its ongoing Phase 1/2 trial evaluating vopimetostat in combination with RAS(ON) inhibitors from Revolution Medicines, Inc. in patients with MTAP-deleted and RAS-mutant metastatic pancreatic ductal adenocarcinoma ("PDAC") and non-small cell lung cancer ("NSCLC"). As of the data cutoff date of August 20, 2026, updated data from the ongoing Phase 1/2…”
Aug 14, 2026Schedule 13G/ANextech Crossover I GP S.a. r.l., Nextech Crossover I SCSp: 0.0% of shares, passive 5%+ holder (amended)
Aug 14, 2026Schedule 13G/ATCG Crossover GP II, LLC, TCG Crossover Fund II, L.P.: 7.0% of shares, passive 5%+ holder (amended)
Aug 14, 2026Schedule 13GTHE GOLDMAN SACHS GROUP, INC., GOLDMAN SACHS & CO. LLC: 6.0% of shares, passive 5%+ holder
Aug 14, 2026Schedule 13G/AWoodline Partners LP: 2.5% of shares, passive 5%+ holder (amended)
Aug 14, 2026Schedule 13G/AFarallon Capital Management, L.L.C., Farallon Capital Partners, L.P.: 9.8% of shares, passive 5%+ holder (amended)
Aug 12, 2026Schedule 13G/AAdage Capital Management, L.P., Robert Atchinson: 3.4% of shares, passive 5%+ holder (amended)
Aug 11, 20268-KOther material event
“As previously disclosed, on November 21, 2025, Tango Therapeutics, Inc. (the "Company") entered into a Sales Agreement (the "Sales Agreement") with Leerink Partners LLC (the "Sales Agent"), with respect to an at-the-market offering program pursuant to which the Company may offer and sell, from time to time at its sole discretion, shares of its common stock, par value $0.001 per share (the "Common Stock"), through the Sales Agent. The Company previously filed a registration statement on Form S-3ASR (File No.…”
Aug 11, 20268-KQuarterly results
Aug 11, 202610-QQuarterly report · period ended Jun 30, 2026
Aug 7, 20268-K/ADirector or executive officer change, or pay arrangement; Regulation FD disclosure
Aug 6, 20268-KDirector or executive officer change, or pay arrangement

Source: SEC EDGAR. Quotes are the opening words of each item as filed; each form links to the filing. Insider Form 4 filings are listed in the insider sections.

TNGX analyst estimates and revisions

PeriodEPS estimate90 days agoChangeRevenue estimateAnalysts
Current quarter (ends Sep 2026)$-0.35$-0.33−$0.02$012
Next quarter (ends Dec 2026)$-0.38$-0.34−$0.03$012
Current fiscal year (ends Dec 2026)$-1.40$-1.29−$0.10$012
Next fiscal year (ends Dec 2027)$-1.69$-1.52−$0.17$2.6M11

Key Statistics (as of October 29, 2026 at 08:45 UTC)

PriceUSD 22.23
Change▼ 2.88% (down)
Previous CloseUSD 22.89
OpenUSD 22.86
Day RangeUSD 22.14 – 23.71
52-Week RangeUSD 7.37 – 34.39
Volume3,309,657 shares
Market Cap$3.75B
ExchangeNGM

Technical Analysis (TNGX)

Nexqual's technical model rates TNGX "SELL" based on 1 bullish and 5 bearish signals across 127 daily candles, as of October 29, 2026 at 08:45 UTC.

Overall SignalSELL
RSI (14)45.32 (neutral)
vs SMA50Below (USD 23.67)
MACD-0.11 (negative)

Analyst Ratings (TNGX)

Wall Street analysts rate TNGX "Buy" based on 13 analysts, with a mean price target of USD 47.09 (range USD 24–69), per Nexqual as of October 29, 2026 at 08:45 UTC.

Consensus RatingBuy
Analyst Count13
Mean TargetUSD 47.09
High TargetUSD 69
Low TargetUSD 24
Buy / Hold / Sell12 / 1 / 0

Earnings (TNGX)

Next Earnings Date2026-11-04
EPS EstimateUSD -0.35
Revenue Estimate$0

Recent Earnings History

QuarterActual vs Estimate
2026-06-30USD -0.37 vs est -0.32 ▼ miss
2026-03-31USD -0.32 vs est -0.31 ▼ miss
2025-12-31USD -0.29 vs est -0.33 ▲ beat
2025-09-30USD 0.13 vs est -0.07 ▲ beat

Source: Nexqual, October 29, 2026 at 08:45 UTC.

Financials & Fundamentals (TNGX)

Total Revenue$53.81M
Gross Margin-148.37%
Operating Margin-253.38%
Profit Margin-229.92%
ROE-21.34%
Debt / Equity0.03
Current Ratio50.82
Total Cash$1.01B
Total Debt$31.99M
Free Cash Flow (last four quarters to Jun 2026, SEC 10-Q / 10-K)-$144.25M (-268.1% of revenue)

Source: Nexqual, October 29, 2026 at 08:45 UTC.

Financial Health Score (TNGX)

Nexqual rates Tango Therapeutics, Inc.'s overall financial health "Mixed" across five dimensions, as of October 29, 2026 at 08:45 UTC.

GrowthStrong — Revenue +48% YoY (annual)
ProfitabilityCritical — Heavily loss-making — early-stage company
Balance SheetStrong — $1.01B cash vs $32M debt, net cash position
Cash FlowWeak — FCF negative: -$144M (last 4 quarters to Jun 2026, SEC), burning cash
EfficiencyCritical — ROE -12%, ROA -11.5% (last 4 quarters, SEC)

Ownership (TNGX)

Insider Ownership+1.19%
Institutional Ownership+128.66%
Shares Outstanding168.61M
Float120.67M
Short % of Float+26.86%

Source: Nexqual, October 29, 2026 at 08:45 UTC.

Leadership (TNGX)

Tango Therapeutics, Inc. is led by Malte Peters, President, CEO & Director, per Nexqual as of October 29, 2026 at 08:45 UTC.

President, CEO & DirectorMalte Peters
President of Research & DevelopmentAdam S. Crystal
Chief Financial OfficerMatthew Gall
Chief Scientific OfficerJannik N. Andersen

Major Backers & Investors (TNGX)

Notable institutional backers of Tango Therapeutics, Inc. include RTW Investments LP, FMR, LLC, Farallon Capital Management LLC, according to Nexqual as of October 29, 2026 at 08:45 UTC.

Active Investors

InvestorStake
RTW Investments LP8.24%
FMR, LLC7.31%
Farallon Capital Management LLC7.28%
Boxer Capital Management, LLC6.45%
Goldman Sachs5.92%
TCG Crossover Management, LLC5.39%
Fidelity4.06%
TRV GP IV, LLC3.78%

Index Funds (Passive)

FundStake
BlackRock7.38%

Source: Nexqual, October 29, 2026 at 08:45 UTC.

From Tango Therapeutics, Inc.'s Latest SEC 10-K Filing (filed 2026-03-05)

Key Strengths & Strategy (as disclosed to the SEC)

Partnerships

Legal & Regulatory Risks (Item 1A, quoted)

Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.

Peers & Related Stocks

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ORKAOruka Therapeutics, Inc.USD 95.97▲ 0.17%
IOVAIovance Biotherapeutics, Inc.USD 14.81▲ 1.58%
IONSIonis Pharmaceuticals, Inc.USD 44.9▲ 2.14%
AXSMAxsome Therapeutics, Inc.USD 143.51▲ 0.92%
PRAXPraxis Precision Medicines, IncUSD 285.48▲ 6.69%

Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 29, 2026 at 08:45 UTC. This page is informational and not investment advice.

For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt