Xencor, Inc. (XNCR) Stock Price & Analysis
Xencor, Inc. (XNCR) closed at USD 29.21 on Thursday, October 29, 2026, down 2.60% on the day. The US market is currently closed (after-hours); this is not a live price.
The prior close was USD 29.99; the Oct 29, 2026 session ranged USD 28.92–30.56 on volume of 930,369 shares. Market capitalization is $2.17B, with a 52-week range of USD 10.38–33.6 (NGM). Source: Nexqual, retrieved October 29, 2026 at 20:49 UTC.
Also available as compact Markdown for AI agents: nexqual.com/XNCR.md
Key facts (XNCR)
- Last four reported quarters (through Jun 30, 2026): revenue $105M, net income -$163M (-155.6% margin), free cash flow -$208M (SEC filings).
- Insider open-market sales, last ~7 months: 6 Form 4 filings, $422K; 1 not under a Rule 10b5-1 plan ($43K); 0 by opportunistic insiders, 0 by routine insiders (three-year test, Cohen, Malloy & Pomorski 2012).
- Analysts: Buy (mean 1.93 on a 1–5 scale) (14 analysts), mean target USD 40.25 (range 21–70).
- Total return with dividends: 1Y +106.7% vs S&P 500 +14.4%; 5Y -26.2% vs S&P 500 +79.1%.
- Next earnings: 2026-11-04, EPS estimate USD -0.34, revenue estimate $63.0M.
Financials (SEC 10-K; TTM = last four 10-Q/10-K quarters) (XNCR)
| USD | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 | TTM |
|---|---|---|---|---|---|---|
| Revenue | $275M | $165M | $175M | $110M | $126M | $105M |
| Operating income | $43.8M | -$82.5M | -$132M | -$178M | -$178M | -$216M |
| Net income | $82.6M | -$55.2M | -$133M | -$233M | -$91.9M | -$163M |
| EPS (diluted) | $1.37 | -$0.93 | -$2.20 | -$3.58 | -$1.24 | — |
| Free cash flow | -$30.2M | -$14.0M | -$96.4M | -$208M | -$138M | -$208M |
| Operating margin | 15.9% | -50.1% | -75.8% | -161.5% | -141.4% | -205.8% |
| Net margin | 30.0% | -33.5% | -76.2% | -210.5% | -73.2% | -155.6% |
| Revenue growth | +124.2% | -40.2% | +6.1% | -36.7% | +13.7% | — |
| Cash + short-term investments | $297M | $581M | $552M | $450M | $435M | — |
| Total debt | — | $0K | $189M | $164M | $120M | — |
Fiscal years end Dec. EPS is split-adjusted.
Valuation (price ÷ last four quarters, through Jun 30, 2026) (XNCR)
P/S 20.7x · EV/Sales 18.1x · P/B 4.3x · FCF yield -9.59% · Earnings yield -7.52% · Net cash $273M · EV $1.90B
Insider sales (SEC Form 4, open-market, last ~7 months) (XNCR)
5 of 6 under a Rule 10b5-1 trading plan (scheduled in advance). Unplanned sales were timed by the insider.
| Trade date | Insider | Role | Shares | Value | % of holdings sold | 10b5-1 plan | Insider type |
|---|---|---|---|---|---|---|---|
| 2026-06-18 | Feigal Ellen | Director | 6,843 | $89K | 35.7% | Yes (adopted June 26, 2025) | Too little history (no open-market trades in 2023) |
| 2026-06-15 | Gorman Kevin Charles | Director | 7,527 | $93K | 39.8% | Yes (adopted June 27, 2025) | Too little history (no open-market trades in 2023) |
| 2026-06-15 | Gustafson Kurt A | Director | 5,474 | $67K | 27.1% | Yes (adopted June 24, 2025) | Too little history (no open-market trades in 2023) |
| 2026-06-15 | Ranieri Richard J | Director | 5,474 | $67K | 28.5% | Yes (adopted June 26, 2025) | Too little history (no open-market trades in 2023) |
| 2026-06-15 | Montgomery Alan Bruce | Director | 5,064 | $62K | 24.6% | Yes (adopted March 4, 2026) | Too little history (no open-market trades in 2023) |
| 2026-04-10 | Cornelissen Bart Jan | SR. VICE PRESIDENT & CFO | 3,499 | $43K | 4.4% | No | Too little history (no open-market trades in 2023 or 2024) |
% of holdings sold = shares sold ÷ (shares sold + all holdings the insider reported on that Form 4, direct and through trusts).
Insider type follows Cohen, Malloy & Pomorski (Journal of Finance, 2012). An insider who traded the stock in the same calendar month in each of the past three years is a routine trader; one who traded in each of those years without such a pattern is an opportunistic trader. In their study, trades by opportunistic insiders predicted future returns and trades by routine insiders did not. Counts open-market purchases and sales only (SEC Form 4 codes P and S) by that insider in that company. Not investment advice.
Analysts (XNCR)
Consensus Buy (mean 1.93 on a 1–5 scale), 14 analysts; mean target USD 40.25 (low 21, high 70).
Rating changes, last 120 days:
| Date | Firm | Action | Rating | Price target |
|---|---|---|---|---|
| 2026-10-27 | Truist Securities | Target raised | Buy | $29 → $40 |
| 2026-10-27 | RBC Capital | Target raised | Outperform | $20 → $43 |
| 2026-10-27 | Wells Fargo | Target raised | Overweight | $30 → $44 |
| 2026-10-27 | Wedbush | Target raised | Outperform | $30 → $45 |
| 2026-10-21 | Wedbush | Reiterated | Outperform | $30 |
| 2026-09-28 | Truist Securities | Target raised | Buy | $27 → $29 |
| 2026-09-21 | B of A Securities | Target raised | Neutral | $20 → $26 |
| 2026-09-11 | Barclays | Target raised | Overweight | $27 → $35 |
| 2026-09-03 | JP Morgan | Target raised | Neutral | $14 → $21 |
| 2026-09-01 | Raymond James | Target raised | Strong Buy | $40 → $46 |
| 2026-08-06 | RBC Capital | Target raised | Outperform | $19 → $20 |
| 2026-08-06 | Wedbush | Target raised | Outperform | $26 → $30 |
Total return (dividends reinvested) (XNCR)
| 1Y (from 2025-10-30) | 5Y (from 2021-10-25) | |
|---|---|---|
| Total return | +106.7% | -26.2% |
| S&P 500 (SPY) | +14.4% | +79.1% |
| Per year | +107.2% | -5.9% |
| Volatility (annualized) | 63.3% | 53.7% |
| Max drawdown | -42.6% (Dec 2025→May 2026) | -82.5% (Nov 2021→Aug 2025) |
XNCR earnings history and stock reaction
| Results filed | Quarter | EPS | Consensus | Surprise | Stock reaction |
|---|---|---|---|---|---|
| Oct 26, 2026 | — | — | — | — | +19.1% |
| Aug 5, 2026 | Quarter ended Jun 30, 2026 | −$0.29 | −$0.84 | Beat +65.5% | +0.4% |
| Jul 29, 2026 | Quarter ended Jun 30, 2026 | −$0.29 | −$0.84 | Beat +65.5% | +7.6% |
| May 6, 2026 | Quarter ended Mar 31, 2026 | −$1.71 | −$0.75 | Miss −128.0% | -4.2% |
| Feb 25, 2026 | Quarter ended Dec 31, 2025 | −$0.09 | −$0.58 | Beat +84.5% | +14.7% |
| Jan 8, 2026 | Quarter ended Sep 30, 2025 | −$0.08 | −$0.70 | Beat +88.6% | -7.1% |
| Nov 5, 2025 | Quarter ended Sep 30, 2025 | −$0.08 | −$0.70 | Beat +88.6% | +2.2% |
| Aug 6, 2025 | — | — | — | — | -7.9% |
EPS as reported against the analyst consensus before the release; surprise uses the cent-rounded figures shown (in dollars when EPS and consensus have opposite signs). Stock reaction = close before the results to close after (the first close following a release after the bell or before the open).
XNCR recent SEC filings (last 120 days)
| Filed | Form | What it says |
|---|---|---|
| Oct 27, 2026 | Schedule 13G/A | BlackRock, Inc.: 14.5% of shares, passive 5%+ holder (amended) |
| Oct 26, 2026 | 8-K | Quarterly results; Regulation FD disclosure; Other material event “On October 25, 2026, the Company issued a press release announcing updated results from the Phase 1 study of XmAb819, an ENPP3 x CD3 T-cell engaging bispecific antibody, in patients with advanced clear cell renal cell carcinoma. A copy of the press release is filed as Exhibit 99.2 to this Current Report on Form 8-K and incorporated herein by reference.” |
| Aug 5, 2026 | 10-Q | Quarterly report · period ended Jun 30, 2026 |
| Aug 5, 2026 | 8-K | Quarterly results |
| Jul 31, 2026 | Schedule 13G | Vanguard Capital Management: 5.1% of shares, passive 5%+ holder |
| Jul 29, 2026 | 8-K | Entered a material agreement; Quarterly results; Regulation FD disclosure “On July 29, 2026, Xencor, Inc. (the "Company") entered into a settlement agreement and release (the "Settlement Agreement"), with Alexion Pharma International Operations Limited, an Irish limited company ("Alexion") with respect to a commercial dispute related to U.S. royalties on Ultomiris (ravulizumab-cwvz). Pursuant to the Settlement Agreement, the Company will receive an aggregate of $105 million in two equal payments: the first $52.5 million payment is anticipated in August 2026 and the second $52.5 million…” |
Source: SEC EDGAR. Quotes are the opening words of each item as filed; each form links to the filing. Insider Form 4 filings are listed in the insider sections.
XNCR revenue by product line (quarter ended Jun 30, 2026)
| Line | Revenue | Share of total | YoY |
|---|---|---|---|
| Royalties | $41.2M | 80.5% | +121.5% |
| Milestone | $10.0M | 19.5% | -60.0% |
| Total revenue | $51.2M | 100% | — |
As tagged by the company in its SEC 10-Q / 10-K filings (XBRL).
XNCR suppliers, customers and competitors (named in its 10-K)
| Relationship | Company | Sentence in the filing |
|---|---|---|
| Partner | AMGEN INC (AMGN) | “Amgen: Xaluritamig is a STEAP1 x CD3 2+1 XmAb bispecific T-cell engager that our partner Amgen is advancing for the treatment of patients with prostate cancer.” |
| Partner | Zenas BioPharma, Inc. (ZBIO) | “Zenas' partner, Bristol Myers Squibb, holds exclusive development and commercialization rights for obexelimab in Japan, South Korea, Taiwan, Hong Kong, Singapore, and Australia.” |
| Partner | WuXi | “Master Services Agreement with WuXi Biologics (Hong Kong) Limited” |
| Partner | INCYTE CORP (INCY) | “Our partnership and license agreements include those we have with J&J, Genentech, Vir, Amgen, Incyte, Alexion and others.” |
| Partner | Alexion Pharmaceuticals | “Our partnership and license agreements include those we have with J&J, Genentech, Vir, Amgen, Incyte, Alexion and others.” |
| Partner | Alimentiv | “In February 2025, we entered into a master services agreement with Alimentiv Inc. for contract research organizations ("CROs") services supporting clinical trial management and development (including site selection, study design, site monitoring, management and training, and patient selection).” |
| Partner | OncoBay Clinical | “In August 2023, we entered into a master services agreement with OncoBay Clinical, Inc., now known as Kapadi, for CROs services supporting clinical trial management and development (including site selection, study design, site monitoring, management and training, and patient selection).” |
| Partner | Vetter Pharma International | “In October 2020, we entered into a master services agreement with Vetter Pharma International GmbH for clinical scale-up, analytical method development, formulation development, and manufacturing of drug product for certain bispecific antibody candidates, including vudalimab and XmAb541.” |
| Partner | ICON Clinical Research | “In April 2016, as amended in April 2021, we entered into a master clinical services agreement with ICON Clinical Research Limited for clinical trial services, including site selection, study design, monitoring, and trial management.” |
| Partner | PPD Development | “In June 2015, we entered into a master services agreement with PPD Development, L.P. for clinical trial management and development services (including site selection, study design, site monitoring, management and training, and patient selection).” |
| Partner | KBI Biopharma | “In July 2014, we entered into a master services agreement with KBI Biopharma, Inc. for process development, clinical scale-up, analytical method development, formulation development, and related drug substance and drug product services for certain antibody candidates, including XmAb541 and plamotamab.” |
| Partner | PAREXEL International | “We entered into a master services agreement with PAREXEL International, LLC in April 2014, as amended from time to time, most recently in April 2025, for CROs services supporting clinical trial management and development (including site selection, study design, site monitoring, management and training, and patient selection).” |
Quoted from the company's 10-K filed Feb 25, 2026.
Companies that name XNCR in their SEC reports
| Relationship to XNCR | Company | Filing | Sentence |
|---|---|---|---|
| partner | Inmune Bio, Inc. (INMB) | 10-K Mar 30, 2026 | “entered into a license agreement with Xencor, Inc. ("Xencor"), which has discovered and developed a proprietary biological” |
| partner | Zenas BioPharma, Inc. (ZBIO) | 10-K Mar 16, 2026 | “In September 2020, we entered into a license agreement (the "2020 Xencor Agreement") with Xencor, to obtain (i) an exclusive, royalty-bearing, sublicensable worldwide license under certain patent rights controlled by Xencor and (ii) a non-exclusive payment bearing license under certain know-how controlled by Xencor to research, develop, manufacture, market and sell three antibody product candidates (the "2020 Lice…” |
| partner | INCYTE CORP (INCY) | 10-K Feb 10, 2026 | “Under the purchase agreement, we also became the successor to MorphoSys under its collaboration and license agreement with Xencor, Inc. ("Xencor"), pursuant to which Xencor granted MorphoSys an exclusive, worldwide license, including the right to sublicense under certain conditions, for tafasitamab.” |
XNCR company outlook (results filed Oct 26, 2026)
- “Patient opportunity1 Patient population F Description Phase 1 Part Phase 1 Part Post-IO + TKI – Establish XmAb819 Monotherapy Post IO-TKI IV monotherapy Post-IO + TKI ~23.9K Ongoing End of Phase 1 meeting 1H 2027 A & B Status Expected Milestone or Readout U.S.”
Quoted word-for-word from the SEC 8-K results press release.
XNCR analyst estimates and revisions
| Period | EPS estimate | 90 days ago | Change | Revenue estimate | Analysts |
|---|---|---|---|---|---|
| Current quarter (ends Sep 2026) | $-0.34 | $-0.83 | +$0.49 | $63.0M | 12 |
| Next quarter (ends Dec 2026) | $-0.79 | $-0.74 | −$0.05 | $30.1M | 12 |
| Current fiscal year (ends Dec 2026) | $-3.07 | $-4.03 | +$0.96 | $148.8M | 12 |
| Next fiscal year (ends Dec 2027) | $-3.54 | $-3.55 | +$0.01 | $121.0M | 12 |
XNCR options: expected move
Options price a move of about ±17.8% (±$5.28) by Nov 20, 2026, which includes earnings on Nov 4, 2026. Over the last 8 reports the stock moved ±7.9% on average.
| Expiration | Days | ATM implied volatility | Expected move |
|---|---|---|---|
| Nov 20, 2026 | 22 | 87.8% | ±17.8% |
| Dec 18, 2026 | 50 | 79.9% | ±24.2% |
| Feb 19, 2027 | 113 | 78.8% | ±35.1% |
| May 21, 2027 | 204 | 73.9% | ±42.5% |
30-day implied volatility 87.3% vs 64.5% realized over the last 30 trading days. Put/call ratio (volume) 0.32. Cboe delayed quotes (15 min). Expected move = at-the-money straddle.
Key Statistics (as of October 29, 2026 at 20:49 UTC)
| Price | USD 29.21 |
|---|---|
| Change | ▼ 2.60% (down) |
| Previous Close | USD 29.99 |
| Open | USD 30.08 |
| Day Range | USD 28.92 – 30.56 |
| 52-Week Range | USD 10.38 – 33.6 |
| Volume | 930,369 shares |
| Market Cap | $2.17B |
| Exchange | NGM |
Technical Analysis (XNCR)
Nexqual's technical model rates XNCR "STRONG BUY" based on 5 bullish and 0 bearish signals across 127 daily candles, as of October 29, 2026 at 20:49 UTC.
| Overall Signal | STRONG BUY |
|---|---|
| RSI (14) | 66.65 (neutral) |
| vs SMA50 | Above (USD 25.68) |
| MACD | 1.15 (positive) |
Analyst Ratings (XNCR)
Wall Street analysts rate XNCR "Buy" based on 14 analysts, with a mean price target of USD 40.25 (range USD 21–70), per Nexqual as of October 29, 2026 at 20:49 UTC.
| Consensus Rating | Buy |
|---|---|
| Analyst Count | 14 |
| Mean Target | USD 40.25 |
| High Target | USD 70 |
| Low Target | USD 21 |
| Buy / Hold / Sell | 12 / 2 / 0 |
Earnings (XNCR)
| Next Earnings Date | 2026-11-04 |
|---|---|
| EPS Estimate | USD -0.34 |
| Revenue Estimate | $62.99M |
Recent Earnings History
| Quarter | Actual vs Estimate |
|---|---|
| 2026-06-30 | USD -0.29 vs est -0.84 ▲ beat |
| 2026-03-31 | USD -1.71 vs est -0.75 ▼ miss |
| 2025-12-31 | USD -0.09 vs est -0.58 ▲ beat |
| 2025-09-30 | USD -0.08 vs est -0.7 ▲ beat |
Source: Nexqual, October 29, 2026 at 20:49 UTC.
Financials & Fundamentals (XNCR)
| Total Revenue | $104.97M |
|---|---|
| Revenue Growth (latest quarter, YoY) | +17.50% |
| Gross Margin | -143.65% |
| Operating Margin | -72.37% |
| Profit Margin | -155.59% |
| ROE | -29.07% |
| Debt / Equity | 0.34 |
| Current Ratio | 6.39 |
| Total Cash | $456.45M |
| Total Debt | $170.11M |
| Free Cash Flow (last four quarters to Jun 2026, SEC 10-Q / 10-K) | -$208.28M (-198.4% of revenue) |
Source: Nexqual, October 29, 2026 at 20:49 UTC.
Financial Health Score (XNCR)
Nexqual rates Xencor, Inc.'s overall financial health "Weak" across five dimensions, as of October 29, 2026 at 20:49 UTC.
| Growth | Solid — Revenue +14% YoY (annual) |
|---|---|
| Profitability | Critical — Heavily loss-making — early-stage company |
| Balance Sheet | Strong — $378M cash and investments vs $105M debt (Jun 2026, SEC), net cash |
| Cash Flow | Weak — FCF negative: -$208M (last 4 quarters to Jun 2026, SEC), burning cash |
| Efficiency | Critical — ROE -32%, ROA -22.5% (last 4 quarters, SEC) |
Ownership (XNCR)
| Insider Ownership | +1.22% |
|---|---|
| Institutional Ownership | +114.68% |
| Shares Outstanding | 74.35M |
| Float | 54.25M |
| Short % of Float | +23.40% |
Source: Nexqual, October 29, 2026 at 20:49 UTC.
Leadership (XNCR)
Xencor, Inc. is led by Bassil I. Dahiyat, Co-Founder, CEO, President & Director, per Nexqual as of October 29, 2026 at 20:49 UTC.
| Co-Founder, CEO, President & Director | Bassil I. Dahiyat |
|---|---|
| Senior VP & CFO | Bart Jan Cornelissen |
| Executive VP of Research & Chief Scientific Officer | John R. Desjarlais |
| Associate Director and Head of Corporate Communications & Investor Relations | Charles Liles |
| Senior VIce President of Human Resources | Jennifer Sandoz |
Major Backers & Investors (XNCR)
Notable institutional backers of Xencor, Inc. include Primecap Management Company, PRIMECAP Odyssey Funds-PRIMECAP Odyssey Aggressive Growth Fund, BVF Inc., according to Nexqual as of October 29, 2026 at 20:49 UTC.
Active Investors
| Investor | Stake |
|---|---|
| Primecap Management Company | 13.69% |
| PRIMECAP Odyssey Funds-PRIMECAP Odyssey Aggressive Growth Fund | 12.69% |
| BVF Inc. | 9.59% |
| RTW Investments LP | 9.12% |
| RA Capital Management, L.P. | 7.09% |
| TCG Crossover Management, LLC | 3.3% |
| Price (T.Rowe) Associates Inc | 3.17% |
Index Funds (Passive)
| Fund | Stake |
|---|---|
| BlackRock | 18.36% |
| Vanguard Group | 7.39% |
| State Street | 6.66% |
Source: Nexqual, October 29, 2026 at 20:49 UTC.
From Xencor, Inc.'s Latest SEC 10-K Filing (filed 2026-02-25)
Key Strengths & Strategy (as disclosed to the SEC)
- In the United States, the FDA regulates drugs and biologic products under the Federal Food, Drug and Cosmetic Act (FDCA), its implementing regulations, and other laws including, in the case of biologics, the Public Health Service Act.
- Biologics require the submission of a Biologics License Application (BLA) to the FDA and approval of the BLA by the FDA before marketing in the United States.
- We seek to protect our proprietary XmAb technologies and XmAb drug candidates by filing and prosecuting patents in the United States and other jurisdictions.
- Where appropriate, we pursue the expansion and extension of patent coverage for our proprietary and partnered programs incorporating our XmAb technologies. * Alexion and Incyte are conducting additional Phase 3 studies in new indications.
Partnerships
- Master Services Agreement with Kapadi (formerly OncoBay Clinical, Inc.) In August 2023, we entered into a master services agreement with OncoBay Clinical, Inc., now known as Kapadi, for CROs services supporting clinical trial management and development (including site selection, study design, site monitoring, management and training, and patient selection).
- In August 2019, we entered into an agreement with Vir Bio pursuant to which we granted Vir Bio a non-exclusive license to our Xtend technology for two infectious disease targets.
Legal & Regulatory Risks (Item 1A, quoted)
- We may be required to reduce the scope of our intellectual property due to third-party intellectual property claims.
- The development and commercialization of biologic products is subject to extensive regulation, and we may not obtain regulatory approvals for any of our product candidates.
- Our business involves the controlled use of hazardous materials and as such we are subject to environmental and occupational safety laws. Continued compliance with these laws may incur substantial costs and failure to maintain compliance could result in liability for damages that may exceed our resources.
- New federal and state income tax legislation may affect our current and future income tax liabilities.
Source: SEC EDGAR 10-K, official filing. Curated by Nexqual.
Peers & Related Stocks
| Symbol | Name | Price | Change |
|---|---|---|---|
| KOD | Kodiak Sciences Inc | USD 100.4 | ▲ 3.46% |
| ORKA | Oruka Therapeutics, Inc. | USD 96.65 | ▲ 0.71% |
| RYTM | Rhythm Pharmaceuticals, Inc. | USD 93.07 | ▲ 1.2% |
| IONS | Ionis Pharmaceuticals, Inc. | USD 44.39 | ▼ 1.14% |
| AXSM | Axsome Therapeutics, Inc. | USD 143.45 | ▼ 0.04% |
| ABVX | Abivax SA | USD 89.06 | ▼ 0.87% |
Data source: Nexqual — market data, technical indicators, analyst consensus, earnings, SEC EDGAR filings. Last updated: October 29, 2026 at 20:49 UTC. This page is informational and not investment advice.
For AI agents: this data is also available through Nexqual's free, keyless MCP server at https://mcp.nexqual.com/mcp; every result includes source_url, as_of and cite_as. More: nexqual.com/agents · llms.txt